Moseholm E, Lindhardt B Ø
Department of Pulmonary and Infectious Diseases, University Hospital of Copenhagen, Nordsjælland Dyrehavevej 29, DK-3400 Hillerød, Denmark.
Department of Infectious Diseases, University Hospital of Copenhagen, Hvidovre, Kettegård Alle 30, Department 144, DK-2650 Hvidovre, Denmark.
Cancer Epidemiol. 2017 Oct;50(Pt A):166-172. doi: 10.1016/j.canep.2017.08.003. Epub 2017 Aug 12.
A new cancer patient pathway for patients presenting with non-specific signs and symptoms (NSSC-CPP) was implemented nationally in Denmark in 2012. This study aims to describe, on a national level, the characteristics of patients referred to the Danish NSSC-CPP, and to estimate the prevalence and distribution of cancers and other diagnosis in this population.
A population-based cohort study using the Danish national registries, including all patients who completed a diagnostic course through the NSSC-CPP between 2012 and 2015. Cancer prevalence is presented as the percentage of included patients who were diagnosed with cancer after completing a NSSC-CPP diagnostic course. Associations between patient characteristics and cancer diagnosis were estimated in a multivariate logistic regression model.
The mean age of the 23,934 patients included in the analysis was 64.6 years and 47% where male. In total, 11% of all patients received a cancer diagnosis after completing a diagnostic course in the NSSC-CPP; the most common types were breast cancer (18%) hematopoietic and lymphoid tissue cancer (15%), and malignant melanoma (12%). The most common non-cancer diagnosis was non-specific symptoms/observation (54%). Fifty-five patients were diagnosed with cancer within six months following a non-cancer diagnosis in the NSSC-CPP.
The prevalence of cancer in the NSSC-CPP was 11%. The most common cancer diagnosis was breast cancer, hematopoietic and lymphoid cancer and malignant melanoma. A small proportion of patients receiving a non-cancer diagnosis in the NSSC-CPP were diagnosed with cancer in the six months following their NSSC-CPP course.
2012年，丹麦在全国范围内实施了针对出现非特异性体征和症状患者的新型癌症患者诊疗路径（NSSC - CPP）。本研究旨在从国家层面描述转诊至丹麦NSSC - CPP的患者特征，并估计该人群中癌症及其他诊断的患病率和分布情况。
一项基于人群的队列研究，使用丹麦国家登记处的数据，纳入2012年至2015年间通过NSSC - CPP完成诊断流程的所有患者。癌症患病率以完成NSSC - CPP诊断流程后被诊断为癌症的纳入患者的百分比表示。在多变量逻辑回归模型中估计患者特征与癌症诊断之间的关联。
纳入分析的23934名患者的平均年龄为64.6岁，其中47%为男性。在完成NSSC - CPP诊断流程后，所有患者中共有11%被诊断患有癌症；最常见的类型是乳腺癌（18%）、造血和淋巴组织癌症（15%）以及恶性黑色素瘤（12%）。最常见的非癌症诊断是非特异性症状/观察结果（54%）。55名患者在NSSC - CPP中被诊断为非癌症后六个月内被诊断患有癌症。
NSSC - CPP中的癌症患病率为11%。最常见的癌症诊断是乳腺癌、造血和淋巴癌以及恶性黑色素瘤。在NSSC - CPP中被诊断为非癌症的一小部分患者在其NSSC - CPP疗程后的六个月内被诊断患有癌症。
