Nappi C, Farace M J, Leone F, Minutolo M, Tommaselli A P, Montemagno U
Eur J Obstet Gynecol Reprod Biol. 1987 Jul;25(3):209-19. doi: 10.1016/0028-2243(87)90101-8.
Nine oligomenorrheic adolescent girls with a clinical and hormonal picture of ovarian hyperandrogenism were treated with a monophasic oral contraceptive (OC) containing 0.03 mg ethinylestradiol (EE) plus 0.150 mg desogestrel (DOG) for six months. The same treatment was administered in eight eumenorrheic adolescents. In both groups the treatment induced a decrease in LH, FSH, androstenedione (delta 4-A), testosterone (T) and dehydroepiandrosterone sulphate (DHEA-S) levels associated with a significant sex-hormone-binding globulin (SHBG) increase. In oligomenorrheic adolescents a marked decrease in both the total ovarian volume and the number of cystic follicles was observed. All parameters, except SHBG and ovarian volume in hyperandrogenic girls, returned to pre-treatment values 3 months after treatment. Subjective improvement of skin problems occurred in six of the nine oligomenorrheic girls. Although temporary, the EE + DOG formulation pill is effective in the treatment of ovarian hyperandrogenism in adolescents. It may also be useful for the prevention of the progressive transformation in the 'classical' and 'irreversible' micropolycystic ovary of adult age.
9名患有卵巢雄激素过多临床和激素表现的月经过少青春期女孩接受了含0.03mg炔雌醇（EE）加0.150mg去氧孕烯（DOG）的单相口服避孕药（OC）治疗6个月。8名月经正常的青少年也接受了相同治疗。两组治疗均导致促黄体生成素（LH）、促卵泡生成素（FSH）、雄烯二酮（δ4-A）、睾酮（T）和硫酸脱氢表雄酮（DHEA-S）水平下降，同时性激素结合球蛋白（SHBG）显著升高。在月经过少的青少年中，观察到卵巢总体积和囊性卵泡数量均明显减少。除了雄激素过多女孩的SHBG和卵巢体积外，所有参数在治疗3个月后均恢复到治疗前水平。9名月经过少女孩中有6名皮肤问题有主观改善。尽管是暂时的，但EE+DOG配方药丸对青少年卵巢雄激素过多症有效。它可能对预防成年期“经典”和“不可逆”微多囊卵巢的进行性转变也有用。
