He Tao, Wang Jie, Wang Xiaoli, Deng Wenshuai, Jiang Hong, Xie Junxia, Sun Peng
Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Gerontology, Affiliated Hospital of Qingdao University, Qingdao, China.
Neurosci Lett. 2017 Sep 14;657:179-188. doi: 10.1016/j.neulet.2017.08.022. Epub 2017 Aug 12.
Recent years, several case-control studies reported that two polymorphisms (rs947211 and 1572913) within the PARK16 locus were associated with the Parkinson's disease (PD). However, the results were still controversial. Herein, we conducted a comprehensive meta-analysis to estimate the associations between two polymorphisms and PD. Seven databases (PubMed, Google Scholar, EMBASE, Web of Science, CNKI (China National Knowledge Infrastructure), VIP and Wanfang) were searched to identify the eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the associations of two polymorphisms with PD susceptibility. Totally, 15 studies with 6637 cases and 6774 controls were included in our meta-analysis. The results showed that rs947211 variants were associated with a decreased risk of PD in overall population. Stratified analysis found that rs947211 variants were associated with a significantly decreased risk of PD in Northeast Asian population, but a slightly decreased risk of PD in Southeast Asian and Caucasian population. With regard to rs1572913 polymorphism, the results suggested that rs1572913 variants contribute to decrease the risk of PD. Therefore, our meta-analysis suggested that rs947211 variants (A allele, AG and GG genotypes) may decrease the risk of PD in overall population, particularly in Northeast Asian population; and T allele, TC and TT genotypes of rs1572913 variants contributed to decrease the risk of PD.
近年来，多项病例对照研究报告称，PARK16基因座内的两个多态性位点（rs947211和1572913）与帕金森病（PD）相关。然而，结果仍存在争议。在此，我们进行了一项全面的荟萃分析，以评估这两个多态性位点与PD之间的关联。检索了七个数据库（PubMed、谷歌学术、EMBASE、科学网、中国知网、维普和万方）以确定符合条件的研究。计算了比值比（OR）及95%置信区间（CI），以评估这两个多态性位点与PD易感性的关联。我们的荟萃分析共纳入了15项研究，涉及6637例病例和6774例对照。结果显示，rs947211变异与总体人群中PD风险降低相关。分层分析发现，rs947211变异与东北亚人群中PD风险显著降低相关，但与东南亚和白种人群中PD风险略有降低相关。关于rs1572913多态性，结果表明rs1572913变异有助于降低PD风险。因此，我们的荟萃分析表明，rs947211变异（A等位基因、AG和GG基因型）可能降低总体人群尤其是东北亚人群中PD的风险；而rs1572913变异的T等位基因、TC和TT基因型有助于降低PD风险。
