Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
J Int Med Res. 2020 Aug;48(8):300060520947943. doi: 10.1177/0300060520947943.
In recent years, a number of case-control studies have focused on the association between the g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed.
Eligible studies concerning the g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case-control studies with 2890 cases and 3043 controls.
This meta-analysis revealed that g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population.
Our meta-analysis suggests that gene variants are not associated with the risk of PD in the overall population.
近年来，许多病例对照研究集中探讨了 g.168_185del 多态性与帕金森病（PD）风险之间的关系。然而，结果存在争议。为了评估 g.168_185del 多态性与 PD 易感性之间的关系，进行了一项综合荟萃分析。
在 PubMed、Web of Science、Embase、万方、CNKI 和 VIP 数据库中检索了与 g.168_185del 多态性与 PD 易感性相关的研究。计算了比值比和 95%置信区间来评估关联的强度。本荟萃分析共纳入了 11 项研究，包括 13 项病例对照研究，共纳入 2890 例病例和 3043 例对照。
这项荟萃分析表明， g.168_185del 变异与非亚洲人群的 PD 易感性相关，但与亚洲人群无关。
我们的荟萃分析表明， g. 基因变异与总体人群 PD 的发病风险无关。
