Siddiqui Ruqaiyyah, Khan Naveed Ahmed
Department of Biological Sciences, School of Science and Technology, Sunway University, Malaysia.
Exp Parasitol. 2017 Dec;183:133-136. doi: 10.1016/j.exppara.2017.08.006. Epub 2017 Aug 12.
Bacterial infections have remained significant despite our advances in the development of a plethora of disinfectants as well as antimicrobial chemotherapy. This is in part due to our incomplete understanding of the prevalence of bacterial pathogens in the environmental and clinical settings. Several lines of evidence suggest that Acanthamoeba is one of the most ubiquitous/resilient protists that also acts as a host/reservoir for pathogenic microbes. Thus targeting the hardy host, which harbour microbial pathogens, offer a potential avenue to counter infection transmission, particularly hospital/community-acquired infections. This will complement existing approach of applying disinfectants that are targeted against bacterial pathogens directly.
尽管我们在开发大量消毒剂以及抗菌化疗方面取得了进展，但细菌感染仍然很严重。这部分是由于我们对环境和临床环境中细菌病原体的流行情况了解不完全。有几条证据表明，棘阿米巴是最普遍/最具韧性的原生生物之一，它还充当致病微生物的宿主/储存库。因此，针对携带微生物病原体的顽强宿主，为对抗感染传播，特别是医院/社区获得性感染提供了一条潜在途径。这将补充现有的直接针对细菌病原体应用消毒剂的方法。
