Sakulchit Teeranai, Benseler Susanne M, Goldman Ran D
Can Fam Physician. 2017 Aug;63(8):607-609.
A 7-year-old child in my office was recently discharged from the hospital after receiving intravenous immunoglobulin for Kawasaki disease. Should I continue treatment with acetylsalicylic acid (ASA), and if so, what is the appropriate dose? The role of ASA for Kawasaki disease during the acute febrile phase has recently been called into question. According to several studies, ASA might reduce the duration of fever but it does not appear to directly reduce the incidence of coronary artery complications. However, with no high-quality randomized controlled trials, the evidence is scarce and more studies with good methodology are needed to determine the value of ASA in the treatment of Kawasaki disease. Currently, guidelines recommending the use of ASA should be followed.
我诊所里有一名7岁儿童，因川崎病接受静脉注射免疫球蛋白治疗后，近期刚出院。我是否应该继续使用乙酰水杨酸（ASA）进行治疗？如果是，合适的剂量是多少？近期，ASA在川崎病急性发热期的作用受到了质疑。根据多项研究，ASA可能会缩短发热持续时间，但似乎并不能直接降低冠状动脉并发症的发生率。然而，由于缺乏高质量的随机对照试验，证据不足，需要更多方法良好的研究来确定ASA在川崎病治疗中的价值。目前，应遵循推荐使用ASA的指南。
