McMurray Jeremy C, May Joseph W, Cunningham Madeleine W, Jones Olcay Y
Department of Pediatrics, Walter Reed National Military Medical Center (WRNMMC), Bethesda, MD, United States.
Division of Pediatric Cardiology, Walter Reed National Military Medical Center (WRNMMC), Bethesda, MD, United States.
Front Pediatr. 2020 Dec 16;8:626182. doi: 10.3389/fped.2020.626182. eCollection 2020.
MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.
儿童多系统炎症综合征（MIS-C）是一种新型定义的、在新冠病毒感染后出现的儿童病毒性心肌炎和炎症性血管病。本综述总结了关于诊断、疾病严重程度参数及当前治疗方案的文献。从潜在的免疫发病机制角度分析了临床观点，并与影响心脏的其他儿童感染后和炎症性疾病进行了比较。在这一模式下，证据支持内皮损伤和IL-1途径激活作为儿童多系统炎症综合征、川崎病和急性风湿热共同决定因素的重要性。
