Abdalla Ahmed, Bachuwa Ghassan, Al Hadidi Samer
Hurley Medical Center, Michigan State University, Flint, MI, USA.
J Community Hosp Intern Med Perspect. 2017 Jul 13;7(3):178-181. doi: 10.1080/20009666.2017.1335155. eCollection 2017 Jul.
Hypercalcemia has many causes including primary hyperparathyroidism, malignancy, and other rare etiologies. In most of the cases, hypercalcemia is secondary to one etiology. In this case, we are reporting hypercalcemia with two causes. The initial workup showed primary hyperparathyroidism due to parathyroid adenoma. But because all features were not fully explained by primary hyperparathyroidism, further work-up revealed multiple myeloma. This case represents coexistence of two different diseases, which was rarely reported in the literature previously. Usually, the co-diagnosis was made subsequently after failure to correct hypercalcemia. In our case, both diagnoses were established at the same time of the patient's presentation as of high suspicion. Establishing the diagnosis early will aid in the initiation of treatment in a timely fashion.
高钙血症有多种病因,包括原发性甲状旁腺功能亢进、恶性肿瘤及其他罕见病因。在大多数情况下,高钙血症继发于一种病因。在此病例中,我们报告的高钙血症有两种病因。初步检查显示因甲状旁腺腺瘤导致原发性甲状旁腺功能亢进。但由于原发性甲状旁腺功能亢进无法完全解释所有特征,进一步检查发现了多发性骨髓瘤。该病例代表了两种不同疾病的共存,此前文献中鲜有报道。通常,在纠正高钙血症失败后才会做出联合诊断。在我们的病例中,由于高度怀疑,在患者就诊时同时确立了两种诊断。早期确立诊断将有助于及时开始治疗。