Reck Tim A, Landmann Gunther
Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.
Spinal Cord Ser Cases. 2017 Aug 10;3:17049. doi: 10.1038/scsandc.2017.49. eCollection 2017.
Neuropathic pain is common in patients with spinal cord injury (SCI) and often difficult to treat. We report a case where epidural spinal cord stimulation (SCS) below the level of injury has been successfully applied in a patient with a complete spinal cord lesion.
A 53-year-old female presented with neuropathic below-level SCI pain of both lower legs and feet due to complete SCI below T5. Time and pain duration since injury was 2 years. Pain intensity was reported on numeric rating scale with an average of 7/10 (0 meaning no pain, 10 meaning the worst imaginable pain), but also with about 8-10 pain attacks during the day with an intensity of 9/10, which lasted between some minutes and half an hour. SCS was applied below the level of injury at-level T11-L1. After a successful 2 weeks testing period the pulse generator has been implanted permanently with a burst-stimulation pattern. The average pain was reduced to a bearable intensity of 4/10, in addition attacks could be reduced both in frequency and in intensity. This effects lasted for at least three months of follow-up.
Even in case of complete SCI, SCS might be effective. Mechanisms of pain relief remain unclear. A modulation of suggested residual spinothalamic tract function may play a role. Further investigation has to be carried out to support this theory.
神经性疼痛在脊髓损伤(SCI)患者中很常见,且往往难以治疗。我们报告了一例成功将损伤平面以下的硬膜外脊髓刺激(SCS)应用于一名完全性脊髓损伤患者的病例。
一名53岁女性因T5以下完全性脊髓损伤出现双下肢和足部损伤平面以下的神经性疼痛。受伤时间和疼痛持续时间为2年。采用数字评分量表报告疼痛强度,平均为7/10(0表示无疼痛,10表示难以想象的最严重疼痛),但白天约有8 - 10次疼痛发作,强度为9/10,每次发作持续数分钟至半小时。在T11 - L1水平损伤平面以下应用SCS。经过为期2周的成功测试期后,脉冲发生器以突发刺激模式永久植入。平均疼痛减轻至可忍受的4/10强度,此外发作的频率和强度均有所降低。这些效果在至少三个月的随访中持续存在。
即使在完全性脊髓损伤的情况下,SCS也可能有效。疼痛缓解的机制尚不清楚。推测残余的脊髓丘脑束功能的调节可能起作用。必须进行进一步研究以支持这一理论。