• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

重组人骨形态发生蛋白-2在脊柱手术中的应用。

Use of recombinant human bone morphogenetic protein-2 in spine surgery.

作者信息

Lykissas Marios, Gkiatas Ioannis

机构信息

Marios Lykissas, Department of Spine Surgery, Metropolitan Hospital, 18547 Athens, Greece.

出版信息

World J Orthop. 2017 Jul 18;8(7):531-535. doi: 10.5312/wjo.v8.i7.531.

DOI:10.5312/wjo.v8.i7.531
PMID:28808623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5534401/
Abstract

Bone morphogenetic proteins are osteoinductive factors which have gained popularity in orthopaedic surgery and especially in spine surgery. The use of recombinant human bone morphogenetic protein-2 has been officially approved by the United States Food and Drug Administration only for single level anterior lumbar interbody fusion, nevertheless it is widely used by many surgeons with off-label indications. Despite advantages in bone formation, its use still remains a controversial issue and several complications have been described by authors who oppose their wide use.

摘要

骨形态发生蛋白是骨诱导因子，在骨科手术尤其是脊柱手术中越来越受欢迎。重组人骨形态发生蛋白-2的使用仅在美国食品药品监督管理局正式批准用于单节段前路腰椎椎间融合术，但许多外科医生仍广泛用于非适应证情况。尽管在骨形成方面有优势，但其使用仍然是一个有争议的问题，反对广泛使用的作者描述了一些并发症。

相似文献

1
Use of recombinant human bone morphogenetic protein-2 in spine surgery.重组人骨形态发生蛋白-2在脊柱手术中的应用。
World J Orthop. 2017 Jul 18;8(7):531-535. doi: 10.5312/wjo.v8.i7.531.
2
Symptomatic ectopic bone formation after off-label use of recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion.经椎间孔腰椎体间融合术使用重组人骨形态发生蛋白-2 超适应证治疗后出现症状性异位骨形成。
J Neurosurg Spine. 2010 Jan;12(1):40-6. doi: 10.3171/2009.4.SPINE0876.
3
A review of the current published spinal literature regarding bone morphogenetic protein-2: an insight into potential bias.一篇关于骨形态发生蛋白-2 的现有脊柱文献综述：潜在偏见的洞察。
Curr Rev Musculoskelet Med. 2014 Sep;7(3):182-8. doi: 10.1007/s12178-014-9221-3.
4
Current Trends in Recombinant Human Bone Morphogenetic Protein 2 (rhBMP2) Usage for Spinal Fusion Surgery.当前在脊柱融合手术中使用重组人骨形态发生蛋白 2（rhBMP2）的趋势。
Medicina (Kaunas). 2023 May 3;59(5):878. doi: 10.3390/medicina59050878.
5
Off-label innovation: characterization through a case study of rhBMP-2 for spinal fusion.非标签创新：通过 rhBMP-2 用于脊柱融合的案例研究进行特征描述。
J Neurosurg Spine. 2016 Sep;25(3):406-14. doi: 10.3171/2016.1.SPINE151192. Epub 2016 Apr 22.
6
Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2.使用椎间融合器和重组人骨形态发生蛋白-2行腰椎前路椎间融合术的6年随访结果
J Bone Joint Surg Am. 2009 May;91(5):1181-9. doi: 10.2106/JBJS.G.01485.
7
Anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2: a prospective study of complications.使用重组人骨形态发生蛋白-2的腰椎前路椎间融合术：并发症的前瞻性研究
J Neurosurg Spine. 2014 Dec;21(6):851-60. doi: 10.3171/2014.8.SPINE13524. Epub 2014 Oct 3.
8
Bone morphogenetic protein use in spine surgery-complications and outcomes: a systematic review.骨形态发生蛋白在脊柱手术中的应用——并发症与结局：一项系统评价
Int Orthop. 2016 Jun;40(6):1309-19. doi: 10.1007/s00264-016-3149-8. Epub 2016 Mar 10.
9
Off-label use of bone morphogenetic proteins in the United States using administrative data.美国基于行政数据评估骨形态发生蛋白的标签外使用。
Spine (Phila Pa 1976). 2010 Sep 1;35(19):1794-800. doi: 10.1097/BRS.0b013e3181ecf6e4.
10
Perioperative complications of recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge versus iliac crest bone graft for posterior cervical arthrodesis.重组人骨形态发生蛋白-2负载可吸收胶原海绵与髂嵴植骨用于颈椎后路融合术的围手术期并发症
Spine (Phila Pa 1976). 2009 Jun 1;34(13):1390-4. doi: 10.1097/BRS.0b013e3181a2da08.

引用本文的文献

1
Off-Label Bone Morphogenetic Protein 2 Use Results in Successful Posterolateral Lumbar Fusion in a Veteran Population.骨形态发生蛋白 2 超适应证使用可成功实现退伍军人人群的后路腰椎融合。
J Am Acad Orthop Surg Glob Res Rev. 2024 Oct 10;8(10). doi: 10.5435/JAAOSGlobal-D-23-00122. eCollection 2024 Oct 1.
2
An Update in Complication Rates Associated With Anterior Lumbar Surgery: A Systematic Review and Meta-Analysis.腰椎前路手术相关并发症发生率的最新情况：一项系统评价和荟萃分析。
Global Spine J. 2025 Mar;15(2):1419-1434. doi: 10.1177/21925682241279526. Epub 2024 Aug 28.
3
Mesenchymal Stem Cell Exosomes Enhance Posterolateral Spinal Fusion in a Rat Model.间充质干细胞外泌体增强大鼠模型后路脊柱融合。
Cells. 2024 Apr 29;13(9):761. doi: 10.3390/cells13090761.
4
Preparation of genetically or chemically engineered exosomes and their therapeutic effects in bone regeneration and anti-inflammation.基因工程或化学工程外泌体的制备及其在骨再生和抗炎中的治疗作用。
Front Bioeng Biotechnol. 2024 Jan 19;12:1329388. doi: 10.3389/fbioe.2024.1329388. eCollection 2024.
5
A pilot study: Nano-hydroxyapatite-PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells.一项初步研究：含低剂量重组人骨形态发生蛋白2的纳米羟基磷灰石-聚乙二醇/聚乳酸刺激人骨髓间充质干细胞的增殖和成骨分化。
JOR Spine. 2023 Jun 1;6(3):e1258. doi: 10.1002/jsp2.1258. eCollection 2023 Sep.
6
An effectiveness and economic analyses of tricalcium phosphate combined with iliac bone graft versus RhBMP-2 in single-level XLIF surgery in Thailand.在泰国的单节段 XLIF 手术中，磷酸三钙联合髂骨移植物与 RhBMP-2 的疗效和经济分析。
BMC Musculoskelet Disord. 2023 Jun 19;24(1):503. doi: 10.1186/s12891-023-06590-9.
7
Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.全身免疫调节改变非愈合性四肢创伤延迟治疗复合模型中的局部骨再生。
Front Surg. 2022 Jul 7;9:934773. doi: 10.3389/fsurg.2022.934773. eCollection 2022.
8
Recombinant human bone morphogenetic protein 2 and 7 inhibit the degeneration of intervertebral discs by blocking the Puma-dependent apoptotic signaling.重组人骨形态发生蛋白 2 和 7 通过阻断 Puma 依赖性凋亡信号抑制椎间盘退变。
Int J Biol Sci. 2021 Jun 11;17(9):2367-2379. doi: 10.7150/ijbs.56823. eCollection 2021.
9
Commercial Bone Grafts Claimed as an Alternative to Autografts: Current Trends for Clinical Applications in Orthopaedics.商业化骨移植材料宣称可替代自体骨移植：骨科临床应用的当前趋势
Materials (Basel). 2021 Jun 14;14(12):3290. doi: 10.3390/ma14123290.
10
Trends in lumbar spinal fusion-a literature review.腰椎融合术的发展趋势——文献综述
J Spine Surg. 2020 Dec;6(4):752-761. doi: 10.21037/jss-20-492.

本文引用的文献

1
Bone morphogenetic protein-2-mediated pain and inflammation in a rat model of posterolateral arthrodesis.骨形态发生蛋白-2介导的后外侧关节融合大鼠模型中的疼痛与炎症
BMC Neurosci. 2016 Dec 1;17(1):80. doi: 10.1186/s12868-016-0314-3.
2
Change in Off-Label Use of Bone Morphogenetic Protein in Spine Surgery and Associations with Adverse Outcome.脊柱手术中骨形态发生蛋白的非标签使用变化及其与不良结局的关联。
Global Spine J. 2016 Nov;6(7):650-659. doi: 10.1055/s-0036-1571284. Epub 2016 Jan 15.
3
Recombinant Human Bone Morphogenetic Protein-2 in Spine Surgery.重组人骨形态发生蛋白-2在脊柱外科手术中的应用
JBJS Rev. 2014 Jun 3;2(6). doi: 10.2106/JBJS.RVW.M.00107.
4
Bone Morphogenetic Protein Use and Cancer Risk Among Patients Undergoing Lumbar Arthrodesis: A Case-Cohort Study Using the SEER-Medicare Database.腰椎融合术患者中骨形态发生蛋白的使用与癌症风险：一项使用监测、流行病学和最终结果-医疗保险数据库的病例队列研究
J Bone Joint Surg Am. 2016 Jul 6;98(13):1064-72. doi: 10.2106/JBJS.15.01106.
5
Factors affecting bone growth.影响骨骼生长的因素。
Am J Orthop (Belle Mead NJ). 2015 Feb;44(2):61-7.
6
A meta analysis of lumbar spinal fusion surgery using bone morphogenetic proteins and autologous iliac crest bone graft.使用骨形态发生蛋白和自体髂嵴骨移植进行腰椎融合手术的荟萃分析。
PLoS One. 2014 Jun 2;9(6):e97049. doi: 10.1371/journal.pone.0097049. eCollection 2014.
7
Nerve injury and recovery after lateral lumbar interbody fusion with and without bone morphogenetic protein-2 augmentation: a cohort-controlled study.后路腰椎体间融合术联合和不联合骨形成蛋白-2 强化治疗对神经损伤及恢复的影响：一项队列对照研究。
Spine J. 2014 Feb 1;14(2):217-24. doi: 10.1016/j.spinee.2013.06.109. Epub 2013 Nov 20.
8
Nerve injury after lateral lumbar interbody fusion: a review of 919 treated levels with identification of risk factors.腰椎侧路椎间融合术后神经损伤：919 个治疗节段的回顾分析及危险因素识别。
Spine J. 2014 May 1;14(5):749-58. doi: 10.1016/j.spinee.2013.06.066. Epub 2013 Sep 5.
9
Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis.使用重组骨形态发生蛋白-2 进行脊柱融合术后的癌症风险。
J Bone Joint Surg Am. 2013 Sep 4;95(17):1537-45. doi: 10.2106/JBJS.L.01483.
10
Complications due to the use of BMP/INFUSE in spine surgery: The evidence continues to mount.脊柱手术中使用骨形态发生蛋白/INFUSE引发的并发症：相关证据不断增加。
Surg Neurol Int. 2013 Jul 9;4(Suppl 5):S343-52. doi: 10.4103/2152-7806.114813. Print 2013.