• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
HLA Class II Allele, Haplotype, and Genotype Associations with Type 1 Diabetes in Benin: A Pilot Study.贝宁 1 型糖尿病与 HLA Ⅱ类等位基因、单倍型和基因型的相关性：一项初步研究。
J Diabetes Res. 2017;2017:6053764. doi: 10.1155/2017/6053764. Epub 2017 Jul 20.
2
Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4.西班牙人群中的1型糖尿病：除II类HLA-DR3和-DR4之外的其他因素。
BMC Genomics. 2005 Apr 20;6:56. doi: 10.1186/1471-2164-6-56.
3
HLA Genetic Discrepancy Between Latent Autoimmune Diabetes in Adults and Type 1 Diabetes: LADA China Study No. 6.成人隐匿性自身免疫性糖尿病与1型糖尿病之间的HLA基因差异：LADA中国研究6号
J Clin Endocrinol Metab. 2016 Apr;101(4):1693-700. doi: 10.1210/jc.2015-3771. Epub 2016 Feb 11.
4
Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients.在韩国1型糖尿病患者中，IA-2体液自身反应性与HLA DR3/4的关联比与DQB1*0201/*0302的关联更紧密。
Ann N Y Acad Sci. 2004 Dec;1037:104-9. doi: 10.1196/annals.1337.015.
5
Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls.人类白细胞抗原（HLA）-DR3单倍型患1型糖尿病的风险取决于基因型背景：DR3和DR4匹配的意大利患者及对照中DPB1与HLA I类基因座的关联
Hum Immunol. 2008 Apr-May;69(4-5):291-300. doi: 10.1016/j.humimm.2008.02.003. Epub 2008 Mar 26.
6
Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan.台湾 1 型糖尿病患者的全面人类白细胞抗原基因分型。
Pediatr Diabetes. 2018 Jun;19(4):699-706. doi: 10.1111/pedi.12645. Epub 2018 Jan 31.
7
Risk genes and autoantibodies in Egyptian children with type 1 diabetes - low frequency of autoantibodies in carriers of the HLA-DRB1*04:05-DQA1*03-DQB1*02 risk haplotype.埃及1型糖尿病儿童的风险基因与自身抗体——HLA-DRB1*04:05-DQA1*03-DQB1*02风险单倍型携带者中自身抗体的低频率
Diabetes Metab Res Rev. 2015 Mar;31(3):287-94. doi: 10.1002/dmrr.2609. Epub 2014 Nov 24.
8
HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes).立陶宛 1 型糖尿病患儿与健康儿童的 HLA Ⅱ类等位基因和单体型（HLA 和 1 型糖尿病）。
Medicina (Kaunas). 2010;46(8):505-10.
9
Diverse human leukocyte antigen association of type 1 diabetes in north India.印度北部 1 型糖尿病与多种人类白细胞抗原相关。
J Diabetes. 2019 Sep;11(9):719-728. doi: 10.1111/1753-0407.12898. Epub 2019 Feb 7.
10
Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset.人类白细胞抗原I类B和C基因座与1型糖尿病（T1D）易感性及T1D发病年龄有关。
Hum Immunol. 2005 Mar;66(3):301-13. doi: 10.1016/j.humimm.2004.12.001.

引用本文的文献

1
Fifty years of HLA-associated type 1 diabetes risk: history, current knowledge, and future directions.50 年的 HLA 相关 1 型糖尿病风险：历史、当前知识和未来方向。
Front Immunol. 2024 Sep 12;15:1457213. doi: 10.3389/fimmu.2024.1457213. eCollection 2024.
2
The phenotype of type 1 diabetes in sub-Saharan Africa.撒哈拉以南非洲 1 型糖尿病的表型。
Front Public Health. 2023 Jan 27;11:1014626. doi: 10.3389/fpubh.2023.1014626. eCollection 2023.

本文引用的文献

1
Life and death of β cells in Type 1 diabetes: A comprehensive review.1型糖尿病中β细胞的生死：综述
J Autoimmun. 2016 Jul;71:51-8. doi: 10.1016/j.jaut.2016.02.001. Epub 2016 Mar 24.
2
Diagnosis and classification of diabetes mellitus.糖尿病的诊断与分类
Diabetes Care. 2014 Jan;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081.
3
Type 1 diabetes.1 型糖尿病。
Lancet. 2014 Jan 4;383(9911):69-82. doi: 10.1016/S0140-6736(13)60591-7. Epub 2013 Jul 26.
4
[Growth and puberty in type 1 diabetes mellitus - experience from a pediatric endocrinology unit].[1型糖尿病的生长与青春期——来自一个儿科内分泌科的经验]
Acta Med Port. 2012 Jul-Aug;25(4):213-8. Epub 2012 Aug 31.
5
Genetics of type 1 diabetes.1 型糖尿病的遗传学。
Clin Chem. 2011 Feb;57(2):176-85. doi: 10.1373/clinchem.2010.148221. Epub 2011 Jan 4.
6
HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes).立陶宛 1 型糖尿病患儿与健康儿童的 HLA Ⅱ类等位基因和单体型（HLA 和 1 型糖尿病）。
Medicina (Kaunas). 2010;46(8):505-10.
7
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.人类白细胞抗原DR-DQ单倍型和基因型与1型糖尿病风险：1型糖尿病遗传学联盟家族分析
Diabetes. 2008 Apr;57(4):1084-92. doi: 10.2337/db07-1331. Epub 2008 Feb 5.
8
The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on.用酸性硫氰酸胍-苯酚-氯仿萃取法进行RNA提取的单步方法：二十多年过去了。
Nat Protoc. 2006;1(2):581-5. doi: 10.1038/nprot.2006.83.
9
[Distribution and frequency of HLA alleles and haplotypes in Brazilians with type 1 diabetes mellitus].[1型糖尿病巴西患者中HLA等位基因和单倍型的分布及频率]
Arq Bras Endocrinol Metabol. 2006 Jun;50(3):436-44. doi: 10.1590/s0004-27302006000300005.
10
Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4.西班牙人群中的1型糖尿病：除II类HLA-DR3和-DR4之外的其他因素。
BMC Genomics. 2005 Apr 20;6:56. doi: 10.1186/1471-2164-6-56.

贝宁 1 型糖尿病与 HLA Ⅱ类等位基因、单倍型和基因型的相关性：一项初步研究。

HLA Class II Allele, Haplotype, and Genotype Associations with Type 1 Diabetes in Benin: A Pilot Study.

机构信息

UFR de Biologie Humaine, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Benin.

Laboratoire de Recherche en Biologie Appliquée, Ecole Polytechnique d'Abomey-Calavi, Université d'Abomey-Calavi, Abomey-Calavi, Benin.

出版信息

J Diabetes Res. 2017;2017:6053764. doi: 10.1155/2017/6053764. Epub 2017 Jul 20.

DOI:10.1155/2017/6053764
PMID:28808665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5541783/
Abstract

BACKGROUND

Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D.

MATERIAL AND METHODS

Class II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes.

RESULTS

Participants were aged 1-24 years. T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1∗03:02, and DQB1∗06:02.

CONCLUSION

Certain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.

摘要

背景

几项研究报告了 HLA-DR/DQ 基因座在 1 型糖尿病（T1D）易感性中的作用。由于贝宁尚未进行此类研究，因此本研究旨在评估 HLA Ⅱ类等位基因、单倍型和基因型与 T1D 的关联。

材料与方法

采用 PCR-SSP 法对 51 例 T1D 患者和 51 例无关健康对照进行Ⅱ类 HLA 基因分型。根据美国糖尿病协会标准诊断 T1D。计算比值比（OR）及其 95%置信区间（95%CI），以评估 T1D 与 HLA 等位基因、单倍型和基因型之间的关联。

结果

参与者年龄为 1-24 岁。T1D 与 DR3、DQA1∗05:01、DQB1∗02:01 和 DR3-DR4 显著相关。与 DR4、DQB1∗03:02 和 DQB1∗06:02 无显著关联。

结论

某些 HLA Ⅱ类等位基因、单倍型和基因型与 T1D 相关，可能作为贝宁 T1D 的遗传易感性标志物。