三氟甲磺酰亚胺酰胺的亚磺酰胺合成。
The Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides.
机构信息
Neuroscience Medicinal Chemistry, Janssen Research & Development , Turnhoutseweg 30, B-2340 Beerse, Belgium.
Neuroscience Medicinal Chemistry, Janssen Research & Development , C/Jarama 75A, 45007 Toledo, Spain.
出版信息
J Org Chem. 2017 Sep 15;82(18):9898-9904. doi: 10.1021/acs.joc.7b01628. Epub 2017 Aug 30.
PMID:28809121
Abstract
A general synthesis of CF-sulfonimidamides from sulfinamides under both batch and continuous flow conditions is described. The reaction proceeds via a sulfonimidoyl fluoride intermediate. A reaction scope showing good group variation on the substituents of both nitrogen atoms is also presented.
摘要
本文描述了在分批和连续流动条件下从亚磺酰胺出发一般合成 CF-磺酰胺的方法。该反应通过磺酰亚胺氟中间体进行。还呈现了在两个氮原子的取代基上具有良好基团变化的反应范围。
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