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关于理解纳米材料危害与管理暴露的共识观点:知识差距与建议

Towards a Consensus View on Understanding Nanomaterials Hazards and Managing Exposure: Knowledge Gaps and Recommendations.

作者信息

Hunt Geoffrey, Lynch Iseult, Cassee Flemming, Handy Richard D, Fernandes Teresa F, Berges Markus, Kuhlbusch Thomas A J, Dusinska Maria, Riediker Michael

机构信息

Centre for Bioethics & Emerging Technologies, St Mary's University College, London, TW1 4SX, UK.

Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, UK.

出版信息

Materials (Basel). 2013 Mar 20;6(3):1090-1117. doi: 10.3390/ma6031090.

Abstract

The aim of this article is to present an overview of salient issues of exposure, characterisation and hazard assessment of nanomaterials as they emerged from the consensus-building of experts undertaken within the four year European Commission coordination project NanoImpactNet. The approach adopted is to consolidate and condense the findings and problem-identification in such a way as to identify knowledge-gaps and generate a set of interim recommendations of use to industry, regulators, research bodies and funders. The categories of recommendation arising from the consensual view address: significant gaps in vital factual knowledge of exposure, characterisation and hazards; the development, dissemination and standardisation of appropriate laboratory protocols; address a wide range of technical issues in establishing an adequate risk assessment platform; the more efficient and coordinated gathering of basic data; greater inter-organisational cooperation; regulatory harmonization; the wider use of the life-cycle approaches; and the wider involvement of all stakeholders in the discussion and solution-finding efforts for nanosafety.

摘要

本文旨在概述纳米材料暴露、特性描述及危害评估的突出问题,这些问题源自欧盟委员会为期四年的协调项目“纳米影响网络”(NanoImpactNet)中专家们达成的共识。所采用的方法是整合并浓缩研究结果及问题识别,以便找出知识空白,并生成一系列对行业、监管机构、研究机构和资助者有用的临时建议。基于共识观点提出的建议类别涉及:暴露、特性描述及危害等关键事实性知识方面的重大空白;适当实验室规程的开发、传播和标准化;建立充分风险评估平台过程中涉及的一系列技术问题;基础数据更高效、协调的收集;加强组织间合作;监管协调统一;更广泛地采用生命周期方法;以及所有利益相关者更广泛地参与纳米安全讨论及解决方案的寻找工作。

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