IST Institut universitaire romand de Santé au Travail Institute for Work and Health, Université de Lausanne + Genève, Lausanne, Switzerland.
J Occup Environ Med. 2012 Oct;54(10):1214-23. doi: 10.1097/JOM.0b013e31826e27f1.
Few epidemiological studies have addressed the health of workers exposed to novel manufactured nanomaterials. The small current workforce will necessitate pooling international cohorts.
A road map was defined for a globally harmonized framework for the careful choice of materials, exposure characterization, identification of study populations, definition of health endpoints, evaluation of appropriateness of study designs, data collection and analysis, and interpretation of the results.
We propose a road map to reach global consensus on these issues. The proposed strategy should ensure that the costs of action are not disproportionate to the potential benefits and that the approach is pragmatic and practical.
We should aim to go beyond the collection of health complaints, illness statistics, or even counts of deaths; the manifestation of such clear endpoints would indicate a failure of preventive measures.
鲜有流行病学研究涉及接触新型人造纳米材料的工人的健康问题。当前的劳动力规模较小，因此有必要汇集国际队列。
为精心选择材料、暴露特征描述、研究人群确定、健康终点定义、研究设计适宜性评估、数据收集和分析以及结果解释制定了全球协调框架。
我们提出了达成这些问题全球共识的路线图。所建议的策略应确保行动成本与潜在收益不成比例，并且方法具有务实性和实用性。
我们的目标不应仅仅停留在收集健康投诉、疾病统计数据甚至死亡人数上；这些明显终点的出现表明预防措施的失败。
