Bagan L, Jiménez Y, Leopoldo M, Murillo-Cortes J, Bagan J
Service of Stomatology and Maxillofacial Surgery, Avda/ Tres Cruces s/n, 46014 Valencia, Spain,
Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e582-e585. doi: 10.4317/medoral.22133.
The main objective of our study was to identify oral symptoms and signs most likely to be associated with the exposure of necrotic bone in bisphosphonate-related osteonecrosis of the jaw (BRONJ).
The study group consisted of 183 patients with BRONJ. We recorded data on the underlying disease, bisphosphonate used, location of osteonecrosis, symptoms, pain, fistula development, suppuration, infection, exposed necrotic bone, and BRONJ stage.
The mean age of the patients was 68.22 ± 12.19 years. The sample included 118 (64.5%) women. Breast cancer and multiple myeloma were the most common underlying diseases, and 50 patients received oral bisphosphonates for osteoporosis. Dental extractions (69.4%) and mandibular location (74.3%) predominated. The only two variables influencing the possibility of necrotic bone exposure were intravenous bisphosphonate administration and the presence of an intraoral fistula (p < 0.05).
Intravenous bisphosphonate use and intraoral fistula presence were associated with a major predisposition to bone exposure in patients with BRONJ.
我们研究的主要目的是确定与双膦酸盐相关颌骨坏死（BRONJ）中坏死骨暴露最可能相关的口腔症状和体征。
研究组由183例BRONJ患者组成。我们记录了基础疾病、使用的双膦酸盐、骨坏死位置、症状、疼痛、瘘管形成、化脓、感染、暴露的坏死骨以及BRONJ分期等数据。
患者的平均年龄为68.22±12.19岁。样本包括118名（64.5%）女性。乳腺癌和多发性骨髓瘤是最常见的基础疾病，50例患者因骨质疏松接受口服双膦酸盐治疗。拔牙（69.4%）和下颌骨部位（74.3%）占主导。影响坏死骨暴露可能性的仅有的两个变量是静脉注射双膦酸盐和口内瘘管的存在（p<0.05）。
静脉注射双膦酸盐的使用和口内瘘管的存在与BRONJ患者骨暴露的主要易感性相关。
