Postgraduate Institute of Medical Education & Research, Chandigarh, India Department of Hepatology.
Ann Hepatol. 2017 Sep-Oct;16(5):818-821. doi: 10.5604/01.3001.0010.2829.
Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepatotoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF. Antibiotics are the most common cause of idiosyncratic DILI as well as DILI induced ALF. Etodolac is a selective cycloxygenase- 2 (COX -2) inhibitor non-steroidal anti-inflammatory drug used as an analgesic and anti-inflammatory in musculoskeletal diseases. Severe liver impairment is extremely rare. Till date, only 3 cases of ALF related to etodolac have been reported in the literature. Here we report two cases with a unique presentation of ALF occurring due to DILI caused by etodolac, as diagnosed by Roussel Uclaf Causality Assessment Method (RUCAM).
药物性肝损伤是急性肝衰竭（ALF）的常见原因。虽然大多数情况下，这些病例是由于对乙酰氨基酚的剂量依赖性肝毒性引起的，但特发性药物性肝损伤（DILI）约占 ALF 病例的 15%。抗生素是导致特发性 DILI 和 DILI 诱导的 ALF 的最常见原因。依托度酸是一种选择性环氧化酶-2（COX-2）抑制剂非甾体抗炎药，用于治疗肌肉骨骼疾病的镇痛和抗炎。严重的肝损伤极为罕见。迄今为止，文献中仅报道了 3 例与依托度酸相关的 ALF 病例。在这里，我们报告了两例由于依托度酸引起的 DILI 导致的 ALF 的独特表现病例，这些病例是通过 Roussel Uclaf Causality Assessment Method（RUCAM）诊断出来的。
