甲氯芬那酸局部制剂对卡拉胶诱导的小鼠足垫肿胀的局部抗炎作用。

The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice.

作者信息

Schrier D J, Moniot S, Gluckman M I, Gilbertsen R B

出版信息

J Pharm Pharmacol. 1987 Jan;39(1):57-9. doi: 10.1111/j.2042-7158.1987.tb07165.x.

DOI:10.1111/j.2042-7158.1987.tb07165.x

Abstract

A topical preparation of meclofenamic acid (Meclomen) was tested for anti-inflammatory activity in a murine model of carrageenan footpad oedema. The preparation significantly inhibited swelling when applied to the carrageenan-injected paw. Maximum inhibition was observed 4-5 h after carrageenan injection. The topical effects could not be attributed to systemic absorption because the preparation was more inhibitory when applied topically to the carrageenan-injected paw than to a distant site or orally.

摘要

在角叉菜胶致小鼠足跖水肿模型中，测试了甲氯芬那酸（甲氯灭酸）局部制剂的抗炎活性。将该制剂应用于注射角叉菜胶的爪子时，可显著抑制肿胀。在注射角叉菜胶后4 - 5小时观察到最大抑制作用。局部作用不能归因于全身吸收，因为该制剂局部应用于注射角叉菜胶的爪子时比应用于远处部位或口服时更具抑制作用。