不同类型黄斑裂孔视网膜毛细血管丛的血管密度
Vascular Density of Retinal Capillary Plexuses in Different Subtypes of Macular Hole.
作者信息
Pierro Luisa, Rabiolo Alessandro, Iuliano Lorenzo, Gagliardi Marco, Panico Davide, Bandello Francesco
出版信息
Ophthalmic Surg Lasers Imaging Retina. 2017 Aug 1;48(8):648-654. doi: 10.3928/23258160-20170802-07.
BACKGROUND AND OBJECTIVE
To compare vessel density and the foveal avascular zone (FAZ) area among eyes with full-thickness macular hole (FTMH), lamellar macular hole (LMH), and macular pseudohole (MPH) using optical coherence tomography angiography (OCTA).
PATIENTS AND METHODS
Cross-sectional study involving 10 eyes with idiopathic FTMH, 10 eyes with LMH, 10 eyes with MPH, 17 unaffected fellow eyes, and 10 healthy controls. All patients underwent 3 mm × 3 mm OCTA centered on the macula. Vessel density and FAZ area were calculated.
RESULTS
In the deep capillary plexus, FTMHs disclosed the highest vessel density (82.7% ± 16.8%), superior to LMHs (63.7% ± 5.9%; P = .0092), MPHs (37.8% ± 2.5%; P = .0011), and controls (53.0% ± 12.2%; P < .0001). In the superficial capillary plexus (SCP), MPHs had the lowest vascular density. Fellow eyes had reduced vascular density at SCP compared to control eyes.
CONCLUSIONS
Microvascular changes are evident in different subtypes of macular holes. Unaffected fellow eyes exhibit early involvement of SCP. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:648-654.].
背景与目的
使用光学相干断层扫描血管造影（OCTA）比较全层黄斑裂孔（FTMH）、板层黄斑裂孔（LMH）和黄斑假性裂孔（MPH）患者眼内的血管密度和黄斑无血管区（FAZ）面积。
患者与方法
一项横断面研究，纳入10例特发性FTMH患者的患眼、10例LMH患者的患眼、10例MPH患者的患眼、17例未受影响的对侧眼以及10例健康对照者。所有患者均接受以黄斑为中心的3mm×3mm OCTA检查。计算血管密度和FAZ面积。
结果
在深层毛细血管丛中，FTMH的血管密度最高（82.7%±16.8%），高于LMH（63.7%±5.9%；P = 0.0092）、MPH（37.8%±2.5%；P = 0.0011）和对照者（53.0%±12.2%；P < 0.0001）。在浅表毛细血管丛（SCP）中，MPH的血管密度最低。与对照眼相比，对侧眼SCP的血管密度降低。
结论
黄斑裂孔的不同亚型存在明显的微血管变化。未受影响的对侧眼表现为SCP早期受累。[《眼科手术、激光与视网膜成像》。2017；48：648 - 654。]
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