Li Y J, Li Y F, Du J W, Dong L H, Gao X, Li G P, Wei X D, Song Y P
Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.
Zhonghua Xue Ye Xue Za Zhi. 2017 Jul 14;38(7):597-601. doi: 10.3760/cma.j.issn.0253-2727.2017.07.009.
To analyze the clinical features, treatment and outcomes of primary lymphoma of bone (PLB) . The clinical data of 11 PLB patients were retrospectively analyzed. 11 patients were enrolled in our study including 7 females and 4 males. The median age of the patients was 45 years old. The main histologic type was diffuse large B cell lymphoma and anaplastic large cell lymphoma. Of the 11 PLB cases, 3 cases were at stage ⅠE, 2 at stage ⅡE, 6 at stage ⅣE respectively. 6 cases were treated with chemotherapy and radiotherapy, 2 cases with total joint arthroplasty and chemotherapy, and 3 cases chemotherapy alone respectively. 5 cases got complete remission, 4 cases partial remission and 2 cases stable disease respectively. The median progression free survival was 17 (5-58) months after a median follow up of 21 (6-58) months. Most of PLB patients were clinically in late stage lacking of clinical and imagine features. The optimal treatment for PLB was radiotherapy combined with chemotherapy, and its prognosis was relatively good.
分析骨原发性淋巴瘤（PLB）的临床特征、治疗方法及预后。回顾性分析11例PLB患者的临床资料。本研究共纳入11例患者，其中女性7例，男性4例。患者的中位年龄为45岁。主要组织学类型为弥漫性大B细胞淋巴瘤和间变性大细胞淋巴瘤。11例PLB病例中，分别有3例为ⅠE期，2例为ⅡE期，6例为ⅣE期。6例接受化疗和放疗，2例接受全关节置换术和化疗，3例仅接受化疗。分别有5例完全缓解，4例部分缓解，2例病情稳定。中位随访21（6 - 58）个月后，中位无进展生存期为17（5 - 58）个月。大多数PLB患者临床分期较晚，缺乏临床及影像学特征。PLB的最佳治疗方法是放疗联合化疗，其预后相对较好。
