Fernhoff P M, Brown A L, Elsas L J
Lancet. 1987 Feb 28;1(8531):490-1. doi: 10.1016/s0140-6736(87)92098-8.
In a population-based screen of 617,913 infants, primary congenital hypothyroidism (CH) was confirmed in 100 children. 32 of the 100 infants with CH had an additional defect or complication. In the group with CH the rates of congenital heart disease, non-cardiac malformations, respiratory distress syndrome, and death were higher than in the general population of the same age. Black infants were less likely than whites to have CH, but were at twice the risk of additional impairment. Infants with CH who had an additional complication were screened (12.7 vs 4.8 days) and treated (32.4 vs 19.7 days) significantly later than those infants with isolated CH. Congenital malformations and neonatal complications should not be reasons for deferring screening for CH.
在一项基于617913名婴儿的人群筛查中，100名儿童被确诊为原发性先天性甲状腺功能减退症（CH）。100名患CH的婴儿中有32名还存在其他缺陷或并发症。患CH的婴儿组中，先天性心脏病、非心脏畸形、呼吸窘迫综合征和死亡的发生率高于同年龄的普通人群。黑人婴儿患CH的可能性低于白人，但出现其他损害的风险是白人的两倍。患有其他并发症的CH婴儿接受筛查（分别为12.7天和4.8天）和治疗（分别为32.4天和19.7天）的时间明显晚于单纯患CH的婴儿。先天性畸形和新生儿并发症不应成为推迟CH筛查的理由。
