van Peer Jacobien M, Enter Dorien, van Steenbergen Henk, Spinhoven Philip, Roelofs Karin
Radboud University Nijmegen, Behavioural Science Institute (BSI), Nijmegen, Montessorilaan 3, PO Box 9104, 6500 HE Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, PO Box 9101, 6500 HB Nijmegen, The Netherlands..
Radboud University Nijmegen, Behavioural Science Institute (BSI), Nijmegen, Montessorilaan 3, PO Box 9104, 6500 HE Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, PO Box 9101, 6500 HB Nijmegen, The Netherlands.; Leiden University, Institute of Psychology, Leiden, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands.
Biol Psychol. 2017 Oct;129:82-89. doi: 10.1016/j.biopsycho.2017.08.003. Epub 2017 Aug 12.
Testosterone plays an important role in social threat processing. Recent evidence suggests that testosterone administration has socially anxiolytic effects, but it remains unknown whether this involves early vigilance or later, more sustained, processing-stages. We investigated the acute effects of testosterone administration on social threat processing in 19 female patients with Social Anxiety Disorder (SAD) and 19 healthy controls. Event-related potentials (ERPs) were recorded during an emotional Stroop task with subliminally presented faces. Testosterone induced qualitative changes in early ERPs (<200ms after stimulus onset) in both groups. An initial testosterone-induced spatial shift reflected a change in the basic processing (N170/VPP) of neutral faces, which was followed by a shift for angry faces suggesting a decrease in early threat bias. These findings suggest that testosterone specifically affects early automatic social information processing. The decreased attentional bias for angry faces explains how testosterone can decrease threat avoidance, which is particularly relevant for SAD.
睾酮在社会威胁处理中起着重要作用。最近的证据表明，给予睾酮具有社会抗焦虑作用，但尚不清楚这是否涉及早期警觉或后期更持续的处理阶段。我们研究了给予睾酮对19名社交焦虑障碍（SAD）女性患者和19名健康对照者社会威胁处理的急性影响。在一项带有阈下呈现面孔的情绪Stroop任务中记录事件相关电位（ERP）。睾酮在两组中均引起早期ERP（刺激开始后<200毫秒）的质性变化。睾酮最初引起的空间偏移反映了中性面孔基本处理（N170/VPP）的变化，随后愤怒面孔也出现偏移，表明早期威胁偏向降低。这些发现表明，睾酮特异性地影响早期自动社会信息处理。对愤怒面孔注意力偏向的降低解释了睾酮如何减少威胁回避，这对社交焦虑障碍尤为重要。
