Jian-Zhen Lin, Jun-Yu Long, An-Qiang Wang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
World J Gastroenterol. 2017 Jul 28;23(28):5045-5050. doi: 10.3748/wjg.v23.i28.5045.
Precision medicine, currently a hotspot in mainstream medicine, has been strongly promoted in recent years. With rapid technological development, such as next-generation sequencing, and fierce competition in molecular targeted drug exploitation, precision medicine represents an advance in science and technology; it also fulfills needs in public health care. The clinical translation and application of precision medicine - especially in the prevention and treatment of tumors - is far from satisfactory; however, the aims of precision medicine deserve approval. Thus, this medical approach is currently in its infancy; it has promising prospects, but it needs to overcome numbers of problems and deficiencies. It is expected that in addition to conventional symptoms and signs, precision medicine will define disease in terms of the underlying molecular characteristics and other environmental susceptibility factors. Those expectations should be realized by constructing a novel data network, integrating clinical data from individual patients and personal genomic background with existing research on the molecular makeup of diseases. In addition, multi-omics analysis and multi-discipline collaboration will become crucial elements in precision medicine. Precision medicine deserves strong support, and its development demands directed momentum. We propose three kinds of impetus (research, application and collaboration impetus) for such directed momentum toward promoting precision medicine and accelerating its clinical translation and application.
精准医学是目前主流医学的一个热点，近年来得到了大力推动。随着下一代测序等技术的快速发展和分子靶向药物开发的激烈竞争，精准医学代表了科技的进步，也满足了公共医疗保健的需求。精准医学的临床转化和应用——特别是在肿瘤的防治方面——远不能令人满意；然而，精准医学的目标值得肯定。因此，这种医学方法目前还处于起步阶段；它具有广阔的前景，但需要克服许多问题和不足。预计精准医学除了常规的症状和体征外，还将根据潜在的分子特征和其他环境易感性因素来定义疾病。这些期望应该通过构建一个新的数据网络来实现，该网络将整合来自个体患者的临床数据和个人基因组背景，以及对疾病分子构成的现有研究。此外，多组学分析和多学科合作将成为精准医学的关键要素。精准医学值得大力支持，其发展需要有针对性的动力。我们提出了三种动力（研究、应用和合作动力）来推动精准医学的发展，加速其临床转化和应用。
