Khan Dur Muhammad, Ullah Aziz, Randhawa Fawad Ahmad, Iqtadar Somia, Butt Nasir Farooq, Waheed Khadija
Dr. Dur Muhammad Khan, FRCP. Department of Medicine, King Edward Medical University, Lahore, Pakistan.
Dr. Aziz Ullah, Department of Medicine, King Edward Medical University, Lahore, Pakistan.
Pak J Med Sci. 2017 May-Jun;33(3):610-614. doi: 10.12669/pjms.333.12397.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic incompletely reversible poor airflow and air trapping and usually this debilitating disorder limits the outside activities of the patients depriving them of sunlight which is a rich source of Vitamin D. The objective of this study was to determine the effect of vitamin D supplementation in reducing number of acute exacerbation in COPD patients.
This randomized control trial was conducted at East Medical Ward Mayo Hospital Lahore from January to December 2015 as exacerbations of COPD are season dependent. Diagnosis was confirmed by performing Pulmonary Function Tests (PFTs). Basic demographical information was obtained and baseline PFTs of the patient was done. Only Group A patients was treated with oral vitamin D intake of 2000 IU daily for 6 months. Vitamin D level was measured at 0, 2, 4, and 6 months and exacerbation of COPD, FEV1 and FVC was measured weekly. Both the groups were given standard treatment for exacerbation of COPD. Spirometry was repeated at each visit. Blood samples were collected every 2 months for vitamin D. Supplementation was stopped if vitamin D level exceeded 100ng/ml.
The mean age of the patients was 46.28±8.83 years, the male to female ratio was 1.8:1. The mean 25(OH) level at baseline was 24.08±2.58 and at 6th month was 29.60±8.74. The mean FVC at baseline was 77.83±5.49 and at 6th month was 91.34±5.52. The exacerbation at baseline was present in all 120(100%) patients and at 6th month was reduced to 4(3.3%).
Vitamin D supplementation has significant effect in reducing number of acute exacerbation in COPD patients when it is given for prolonged period.
慢性阻塞性肺疾病（COPD）的特征为慢性不完全可逆性气流受限和气体潴留，这种使人衰弱的疾病通常会限制患者的户外活动，使他们无法接触富含维生素D的阳光。本研究的目的是确定补充维生素D对减少COPD患者急性加重次数的影响。
由于COPD急性加重具有季节依赖性，本随机对照试验于2015年1月至12月在拉合尔梅奥医院东部内科病房进行。通过进行肺功能测试（PFT）确诊。获取基本人口统计学信息并进行患者的基线肺功能测试。仅A组患者每天口服2000 IU维生素D，持续6个月。在0、2、4和6个月时测量维生素D水平，每周测量COPD急性加重情况、第一秒用力呼气容积（FEV1）和用力肺活量（FVC）。两组均给予COPD急性加重的标准治疗。每次就诊时重复进行肺量计检查。每2个月采集一次血液样本检测维生素D。如果维生素D水平超过100ng/ml，则停止补充。
患者的平均年龄为46.28±8.83岁，男女比例为1.8:1。基线时平均25（OH）水平为24.08±2.58，第6个月时为29.60±8.74。基线时平均FVC为77.83±5.49，第6个月时为91.34±5.52。所有120例（100%）患者在基线时均有急性加重，第6个月时减少至4例（3.3%）。
长期给予维生素D补充剂对减少COPD患者急性加重次数有显著效果。
