van den Berg Maayken Elizabeth Louise, Castellote Juan M, Mayordomo Jose Ignacio, Mahillo-Fernandez Ignacio, de Pedro-Cuesta Jesus
Department of Rehabilitation, Aged and Extended Care, Flinders University, Adelaide, SA, Australia.
National School of Occupational Medicine, Carlos III Institute of Health, Madrid, Spain.
Biomed Res Int. 2017;2017:2478197. doi: 10.1155/2017/2478197. Epub 2017 Jul 25.
Understanding the presentation of spinal cord injury (SCI) due to tumours considering population distribution and temporal trends is key to managing SCI health services. This study quantified incidence rates, function scores, and trends of SCI due to tumour or metastasis over an 18-year time period in a defined region in Spain.
A retrospective cohort study included in-and outpatients with nontraumatic SCI due to tumour or metastasis admitted to a metropolitan hospital in Spain between 1991 and 2008. Main outcome measures were crude and age- and sex-adjusted incidence rates, tumour location and type, distribution by spinal level, neurological level of injury, and impairment ASIA scores.
Primary tumour or metastasis accounted for 32.5% of nontraumatic SCI with an incidence rate of 4.1 per million population. Increasing rates with age and over time were observed. Major pathology groups were intradural-extramedullary masses from which meningiomas and neurinomas accounted for 40%. Lesions were mostly incomplete with predominant ASIA Grade D.
Increasing incidence rates of tumour-related SCI over time in the middle-aged and the elderly suggest a growing need for neurooncology health resources in the future.
了解因肿瘤导致的脊髓损伤（SCI）的表现，考虑人群分布和时间趋势，对于管理SCI医疗服务至关重要。本研究对西班牙某特定地区18年间因肿瘤或转移导致的SCI的发病率、功能评分及趋势进行了量化。
一项回顾性队列研究纳入了1991年至2008年间因肿瘤或转移导致非创伤性SCI而入住西班牙一家大都市医院的门诊和住院患者。主要结局指标为粗发病率、年龄和性别调整发病率、肿瘤位置和类型、脊髓节段分布、损伤神经节段及美国脊髓损伤协会（ASIA）损伤评分。
原发性肿瘤或转移占非创伤性SCI的32.5%，发病率为每百万人口4.1例。观察到发病率随年龄增长及时间推移而上升。主要病理类型为硬脊膜内髓外肿块，其中脑膜瘤和神经鞘瘤占40%。损伤大多不完全，主要为ASIA D级。
中年和老年人群中与肿瘤相关的SCI发病率随时间上升，提示未来对神经肿瘤医疗资源的需求不断增加。
