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An anonymous genomic clone that detects a frequent RFLP adjacent to the D4S10 (G8) marker and Huntington's disease.

作者信息

Carlock L R, Vo T D, DeHaven C R, Murray J C

出版信息

Nucleic Acids Res. 1987 Jan 12;15(1):377. doi: 10.1093/nar/15.1.377.

DOI:10.1093/nar/15.1.377
PMID:2881254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC340430/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c46/340430/2981fc44b736/nar00245-0381-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c46/340430/2981fc44b736/nar00245-0381-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c46/340430/2981fc44b736/nar00245-0381-a.jpg

相似文献

1
An anonymous genomic clone that detects a frequent RFLP adjacent to the D4S10 (G8) marker and Huntington's disease.
Nucleic Acids Res. 1987 Jan 12;15(1):377. doi: 10.1093/nar/15.1.377.
2
Mapping of the DNA locus D4S10 and the linked Huntington's disease gene to 4p16----p15.DNA位点D4S10及相关的亨廷顿氏病基因定位于4p16----p15。
Cytogenet Cell Genet. 1986;42(4):187-90. doi: 10.1159/000132276.
3
Two additional RFLPs at the D4S10 locus, useful for Huntington's disease (HD)-family studies.位于D4S10位点的另外两个限制性片段长度多态性，对亨廷顿舞蹈病（HD）家系研究有用。
Nucleic Acids Res. 1987 Nov 11;15(21):9100. doi: 10.1093/nar/15.21.9100.
4
Chromosome jumping from D4S10 (G8) toward the Huntington disease gene.从D4S10（G8）向亨廷顿舞蹈病基因的染色体跳跃
Proc Natl Acad Sci U S A. 1988 Sep;85(17):6437-41. doi: 10.1073/pnas.85.17.6437.
5
Sequence analysis of three polymorphic regions in the human genome detected by the G8 probe for RFLPs associated with Huntington's disease.用与亨廷顿氏病相关的限制性片段长度多态性（RFLP）的G8探针检测人类基因组中三个多态性区域的序列分析。
Nucleic Acids Res. 1988 Mar 25;16(6):2735. doi: 10.1093/nar/16.6.2735.
6
Genetic linkage between Huntington's disease and D4S10 (G8) in Scottish families.
Clin Genet. 1989 Feb;35(2):133-8. doi: 10.1111/j.1399-0004.1989.tb02918.x.
7
A highly polymorphic locus very tightly linked to the Huntington's disease gene.一个与亨廷顿舞蹈症基因紧密连锁的高度多态性位点。
Nature. 1988 Apr 21;332(6166):734-6. doi: 10.1038/332734a0.
8
Mapping of recombinants near the Huntington disease locus by using G8 (D4S10) and newly isolated markers in the D4S10 region.利用G8（D4S10）及在D4S10区域新分离出的标记对亨廷顿病基因座附近的重组体进行定位。
Am J Hum Genet. 1989 Apr;44(4):560-6.
9
A DNA segment encoding two genes very tightly linked to Huntington's disease.一段编码与亨廷顿舞蹈症紧密连锁的两个基因的DNA片段。
Science. 1987 Nov 13;238(4829):950-2. doi: 10.1126/science.2890209.
10
Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker.
DNA. 1987 Oct;6(5):401-7. doi: 10.1089/dna.1987.6.401.

引用本文的文献

1
Considerations in using linkage analysis as a presymptomatic test for Huntington's disease.将连锁分析用作亨廷顿舞蹈症症状前检测的考量因素。
J Med Genet. 1988 Sep;25(9):577-88. doi: 10.1136/jmg.25.9.577.
2
A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates.一份详细的人类4号染色体多点图谱为连锁异质性和位置特异性重组率提供了证据。
Am J Hum Genet. 1991 May;48(5):911-25.
3
Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.

本文引用的文献

1
Huntington disease-linked restriction fragment length polymorphism localized within band p16.1 of chromosome 4 by in situ hybridization.通过原位杂交将与亨廷顿病相关的限制性片段长度多态性定位在4号染色体的p16.1带内。
Am J Hum Genet. 1986 Sep;39(3):383-91.
在荷兰人群中，亨廷顿舞蹈症基因与D4S10和D4S95基因座之间存在显著的连锁不平衡。
Am J Hum Genet. 1992 Oct;51(4):730-5.