• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Inflammatory Bowel Disease and the NLRP3 Inflammasome.

作者信息

Kanneganti Thirumala-Devi

机构信息

From the Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.

出版信息

N Engl J Med. 2017 Aug 17;377(7):694-696. doi: 10.1056/NEJMcibr1706536.

DOI:10.1056/NEJMcibr1706536
PMID:28813221
Abstract
摘要

相似文献

1
Inflammatory Bowel Disease and the NLRP3 Inflammasome.炎症性肠病与NLRP3炎性小体
N Engl J Med. 2017 Aug 17;377(7):694-696. doi: 10.1056/NEJMcibr1706536.
2
ADP/P2Y aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation.ADP/P2Y 通过 ERK5 介导的 NLRP3 炎性小体激活加重炎症性肠病。
Mucosal Immunol. 2020 Nov;13(6):931-945. doi: 10.1038/s41385-020-0307-5. Epub 2020 Jun 9.
3
Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.白细胞介素1β介导白细胞介素10受体缺陷小鼠和患者的肠道炎症。
Gastroenterology. 2016 Dec;151(6):1100-1104. doi: 10.1053/j.gastro.2016.08.055. Epub 2016 Sep 28.
4
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.髓系来源的miR-223通过抑制NLRP3炎性小体调节肠道炎症。
J Exp Med. 2017 Jun 5;214(6):1737-1752. doi: 10.1084/jem.20160462. Epub 2017 May 9.
5
Galectin-3 Plays an Important Pro-inflammatory Role in the Induction Phase of Acute Colitis by Promoting Activation of NLRP3 Inflammasome and Production of IL-1β in Macrophages.半乳糖凝集素-3通过促进巨噬细胞中NLRP3炎性小体的激活和白细胞介素-1β的产生,在急性结肠炎的诱导期发挥重要的促炎作用。
J Crohns Colitis. 2016 May;10(5):593-606. doi: 10.1093/ecco-jcc/jjw013. Epub 2016 Jan 19.
6
Interaction between autophagy and the NLRP3 inflammasome.自噬与 NLRP3 炎性小体的相互作用。
Acta Biochim Biophys Sin (Shanghai). 2019 Nov 18;51(11):1087-1095. doi: 10.1093/abbs/gmz098.
7
Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome.二氧化钛纳米颗粒加剧葡聚糖硫酸钠诱导的结肠炎:NLRP3炎性小体的作用
Gut. 2017 Jul;66(7):1216-1224. doi: 10.1136/gutjnl-2015-310297. Epub 2016 Feb 4.
8
Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes.巨噬细胞和单核细胞中C5a受体与NLRP3炎性小体之间的双向串扰
Mediators Inflamm. 2016;2016:1340156. doi: 10.1155/2016/1340156. Epub 2016 Jun 7.
9
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.Jmjd3调节炎性小体激活并加重右旋糖酐硫酸钠诱导的小鼠结肠炎。
FASEB J. 2020 Mar;34(3):4107-4119. doi: 10.1096/fj.201902200RR. Epub 2020 Jan 23.
10
Role of NLRP3 inflammasome in inflammatory bowel diseases.NLRP3 炎性小体在炎症性肠病中的作用。
World J Gastroenterol. 2019 Sep 7;25(33):4796-4804. doi: 10.3748/wjg.v25.i33.4796.

引用本文的文献

1
Random forest-driven mortality prediction in critical IBD care: a dual-database model integrating comorbidity patterns and real-time physiometrics.随机森林驱动的重症炎症性肠病护理中的死亡率预测:一种整合共病模式和实时生理指标的双数据库模型
Front Med (Lausanne). 2025 Aug 8;12:1624899. doi: 10.3389/fmed.2025.1624899. eCollection 2025.
2
Antcin-H, a natural triterpene derived from , ameliorates dextran sulfate sodium-induced colitis in mice by inhibiting the NLRP3 inflammasome.安特菌素-H,一种源自[具体来源未给出]的天然三萜类化合物,通过抑制NLRP3炎性小体改善葡聚糖硫酸钠诱导的小鼠结肠炎。
J Tradit Complement Med. 2024 Mar 30;15(4):343-355. doi: 10.1016/j.jtcme.2024.03.016. eCollection 2025 Jul.
3
Remarkable increase in Interleukin-5 receptor expression beyond tissue eosinophils in inflammatory bowel disease.
炎症性肠病中白细胞介素-5受体表达显著增加,超出组织嗜酸性粒细胞水平。
Front Immunol. 2025 May 22;16:1589421. doi: 10.3389/fimmu.2025.1589421. eCollection 2025.
4
The role of fecal microbiota transplantation on the NLRP3-Caspase 1 pathway and anxiety like behavioral in the ulcerative colitis model in rats.粪便微生物群移植对大鼠溃疡性结肠炎模型中NLRP3-半胱天冬酶1通路及焦虑样行为的作用
Sci Rep. 2025 Apr 28;15(1):14831. doi: 10.1038/s41598-025-96948-x.
5
Unveiling the Role of GRK2: From Immune Regulation to Cancer Therapeutics.揭示GRK2的作用:从免疫调节到癌症治疗
Mediators Inflamm. 2025 Mar 5;2025:8837640. doi: 10.1155/mi/8837640. eCollection 2025.
6
Relating the molecular phenotype of ulcerative colitis to the clinical course.将溃疡性结肠炎的分子表型与临床病程相关联。
Sci Rep. 2025 Mar 11;15(1):8342. doi: 10.1038/s41598-025-90618-8.
7
Research Progress with Atractylone as an Antitumor Agent.白术抗肿瘤作用的研究进展。
Molecules. 2024 Nov 19;29(22):5450. doi: 10.3390/molecules29225450.
8
Gain-of-Function Variant in Spleen Tyrosine Kinase Regulates Macrophage Migration and Functions to Promote Intestinal Inflammation.脾酪氨酸激酶功能获得性变异调节巨噬细胞迁移并促进肠道炎症
J Inflamm Res. 2024 Nov 12;17:8713-8726. doi: 10.2147/JIR.S488901. eCollection 2024.
9
Sinapic Acid Attenuates Chronic DSS-Induced Intestinal Fibrosis in C57BL/6J Mice by Modulating NLRP3 Inflammasome Activation and the Autophagy Pathway.芥子酸通过调节NLRP3炎性小体激活和自噬途径减轻慢性右旋糖酐硫酸钠诱导的C57BL/6J小鼠肠道纤维化。
ACS Omega. 2023 Dec 26;9(1):1230-1241. doi: 10.1021/acsomega.3c07474. eCollection 2024 Jan 9.
10
Natural products modulate NLRP3 in ulcerative colitis.天然产物调节溃疡性结肠炎中的NLRP3。
Front Pharmacol. 2023 Oct 2;14:1265825. doi: 10.3389/fphar.2023.1265825. eCollection 2023.