Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands.
Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands.
Immunity. 2017 Aug 15;47(2):209-211. doi: 10.1016/j.immuni.2017.08.002.
Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select active enhancers by interfering with enhancer-binding transcription factor MAF.
干扰素（IFN）-γ 可通过多种机制为巨噬细胞引发炎症反应做好准备，包括增强子的建立和基因激活。在本期《免疫》中，Kang 等人（2017 年）深入研究了 IFN-γ 介导的基因抑制机制，表明 IFN-γ 通过干扰增强子结合转录因子 MAF 促进了特定活性增强子的解体。
