GR 熄灭炎症染色质，NF-κB 撤离。
GR Extinguishes Inflamed Chromatin, and NF-κB Evacuates.
机构信息
Department of Genetics, Institute for Immunology, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Genetics, Institute for Immunology, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Immunity. 2017 Aug 15;47(2):214-216. doi: 10.1016/j.immuni.2017.07.025.
In this issue of Immunity,Oh et al. (2017) provide insight into the molecular effects of glucocorticoid receptor (GR) activation at a clinically relevant time point, after an inflammatory stimulus. They report that GR activation causes a global reduction in NF-κB binding, as well as time-dependent transcriptional effects.
在本期《免疫》杂志中，Oh 等人（2017 年）提供了糖皮质激素受体（GR）在炎症刺激后临床相关时间点激活的分子作用的深入了解。他们报告说，GR 激活导致 NF-κB 结合的整体减少，以及时依赖的转录效应。
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