Fcγ受体功能与疫苗接种策略的设计
Fcγ Receptor Function and the Design of Vaccination Strategies.
作者信息
Bournazos Stylianos, Ravetch Jeffrey V
机构信息
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
出版信息
Immunity. 2017 Aug 15;47(2):224-233. doi: 10.1016/j.immuni.2017.07.009.
Through specific interactions with distinct types of Fcγ receptors (FcγRs), the Fc domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological functions that influence both innate and adaptive responses. Recent studies indicate that IgG Fc-FcγR interactions are dynamically regulated during an immune response through the control of the Fc-associated glycan structure and Ig subclass composition on the one hand and selective FcγR expression on immune cells on the other, which together determine the capacity of IgG to interact in a cell-type-specific manner with specific members of the FcγR family. Here, we present a framework that synthesizes the current understanding of the contribution of FcγR pathways to the induction and regulation of antibody and T cell responses. Within this context, we discuss vaccination strategies to elicit broad and potent immune responses based on the immunomodulatory properties of Fc-FcγR interactions.
通过与不同类型的Fcγ受体（FcγRs）进行特异性相互作用，免疫球蛋白G（IgG）的Fc结构域介导了广泛的免疫功能，这些功能影响先天性和适应性免疫反应。最近的研究表明，IgG Fc-FcγR相互作用在免疫反应过程中受到动态调节，一方面通过控制Fc相关聚糖结构和Ig亚类组成，另一方面通过免疫细胞上FcγR的选择性表达，这两者共同决定了IgG以细胞类型特异性方式与FcγR家族特定成员相互作用的能力。在这里，我们提出了一个框架，综合了目前对FcγR途径在抗体和T细胞反应的诱导和调节中所起作用的理解。在此背景下，我们讨论基于Fc-FcγR相互作用的免疫调节特性引发广泛而有效的免疫反应的疫苗接种策略。
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