Krejcí I, Dlabac A, Vanzura J, Kosnar J
Act Nerv Super (Praha). 1986 Dec;28(4):241-6.
Cyclo (1-amino-1-cyclopentane-carbonyl-L-alanyl)-c(Acp-Ala), a derivative of MIF (prolyl-leucyl-glycinamide) affected passive avoidance behavior of rats when administered at different phases of the step-through type of experimental paradigm. c(Acp-Ala) given s.c. or orally in a 1 mg/kg dose increased avoidance latencies not only when administered before, or immediately after the shock trial but also when given before the pretraining trial, i.e. at the first exposure of animals to the experimental situation without shock treatment. The notion is discussed, that it is the influence of c(Acp-Ala) on processing of information received during the pretraining trial that manifests itself in the facilitation of avoidance response. The drug appears to have a long-term action since it was active when given 20 h before the pretraining trial or the shock trial or the test of retention. c(Acp-Ala) when administered immediately after the shock trial, attenuated amnesia in rats induced by electroconvulsive shock (ECS).
环（1-氨基-1-环戊烷甲酰基-L-丙氨酰基）-c（Acp-Ala），一种巨噬细胞移动抑制因子（脯氨酰-亮氨酰-甘氨酰胺）的衍生物，在穿梭箱实验范式的不同阶段给药时，会影响大鼠的被动回避行为。以1mg/kg剂量皮下或口服给予c（Acp-Ala），不仅在电击试验前或电击试验后立即给药时会增加回避潜伏期，而且在预训练试验前给药时也会增加回避潜伏期，即在动物首次暴露于无电击处理的实验情境时给药。文中讨论了这样一种观点，即c（Acp-Ala）对预训练试验期间接收到的信息处理过程产生影响，从而表现为对回避反应的促进作用。该药物似乎具有长期作用，因为在预训练试验、电击试验或记忆保持测试前20小时给药时它仍有活性。在电击试验后立即给予c（Acp-Ala），可减轻电惊厥休克（ECS）诱导的大鼠失忆。
