Mayer M
Acta Virol. 1986 Nov;30(6):507-11.
Effect of some drugs influencing arachidonic acid metabolic pathways upon the measles virus-induced leukocyte adherence inhibition was investigated in multiple sclerosis patients and in the control group. The drugs used were natrium salicylate, ethanol, and phenidon(1-phenyl-3-pyrazolidon). Statistically significant differences were proved between multiple sclerosis patients and controls using phenidon, a drug inhibiting both cyclooxygenase and lipoxygenase pathways of the arachidonic acid metabolism. The results obtained provide suggestion on participation of arachidonic acid metabolism in the measles virus-induced leukocyte adherence inhibition phenomenon and in its alterations in multiple sclerosis.
在多发性硬化症患者和对照组中，研究了一些影响花生四烯酸代谢途径的药物对麻疹病毒诱导的白细胞黏附抑制的作用。所用药物为水杨酸钠、乙醇和非那宗（1-苯基-3-吡唑啉酮）。使用非那宗（一种抑制花生四烯酸代谢的环氧化酶和脂氧化酶途径的药物）时，多发性硬化症患者和对照组之间存在统计学上的显著差异。所得结果提示花生四烯酸代谢参与了麻疹病毒诱导的白细胞黏附抑制现象及其在多发性硬化症中的改变。
