Measles virus-induced mononuclear leukocyte adherence inhibition: effect of some drugs influencing arachidonic acid metabolic pathways.

Effect of some drugs influencing arachidonic acid metabolic pathways upon the measles virus-induced leukocyte adherence inhibition was investigated in multiple sclerosis patients and in the control group. The drugs used were natrium salicylate, ethanol, and phenidon(1-phenyl-3-pyrazolidon). Statistically significant differences were proved between multiple sclerosis patients and controls using phenidon, a drug inhibiting both cyclooxygenase and lipoxygenase pathways of the arachidonic acid metabolism. The results obtained provide suggestion on participation of arachidonic acid metabolism in the measles virus-induced leukocyte adherence inhibition phenomenon and in its alterations in multiple sclerosis.