Levy N L, Auerbach P S, Hayes E C
N Engl J Med. 1976 Jun 24;294(26):1423-7. doi: 10.1056/NEJM197606242942604.
The increased capacity of lymphocytes from patients with multiple sclerosis to adhere to human epithelial cells persistently infected with measles virus has provided an accurate blood test for multiple sclerosis. When lymphocytes from affected patients were mixed with measles-infected human epithelial cells, the lymphocytes formed rosettes around a mean (+/-S.E.) of 69.2 +/-1.7% of the measles-infected cells. In contrast, lymphocytes from controls, either healthy or with other neurologic and non-neurologic diseases, formed rosettes around a mean of only 28.2+/-2.1% of the measles-infected cells. Of greater importance was the complete absence of overlap between multiple sclerosis and control values, thus indicating the diagnostic potential of the rosetting phenomenon. The severity, duration and activity of the disease had no effect on the degree of rosette formation.
多发性硬化症患者的淋巴细胞与持续感染麻疹病毒的人上皮细胞黏附能力增强，这为多发性硬化症提供了一种准确的血液检测方法。当将患病患者的淋巴细胞与感染麻疹的人上皮细胞混合时，淋巴细胞会在平均（±标准误）69.2±1.7%的感染麻疹细胞周围形成玫瑰花结。相比之下，来自健康对照或患有其他神经和非神经疾病的对照的淋巴细胞，仅在平均28.2±2.1%的感染麻疹细胞周围形成玫瑰花结。更重要的是，多发性硬化症患者与对照的值完全没有重叠，因此表明玫瑰花结形成现象具有诊断潜力。疾病的严重程度、持续时间和活动度对玫瑰花结形成程度没有影响。
