Chelly J E, Doursout M F, Buckley J P
Am J Physiol. 1987 Mar;252(3 Pt 2):R594-8. doi: 10.1152/ajpregu.1987.252.3.R594.
Microinjections of L-glutamate (10(-10) to 2 X 10(-8) mol/kg) into the nucleus of tractus solitarii produced a dose-dependent increase in mean arterial pressure and a decrease in heart rate. L-Glutamate-induced hypertension was prevented by spinal transection and pretreatment with atropine (1 mg/kg iv) reversed the bradycardia. L-Glutamate also produced a dose-dependent increase in mean arterial pressure when injected intravenously and into the cisterna magna, but the dose-effect curves were shifted to the right. Finally, pretreatment with hexamethonium (30 mg/kg iv) abolished the hypertension resulting from intravenous injections of L-glutamate. These data demonstrate that the nucleus of tractus solitarii may play a determinant role in the central pressor effects of L-glutamate. In addition, we demonstrated that this hypertension was due to a central sympathetic stimulation and that the autonomic nervous system also mediated the pressor effects of intravenous L-glutamate.
向孤束核微量注射L-谷氨酸（10⁻¹⁰至2×10⁻⁸摩尔/千克）可使平均动脉压呈剂量依赖性升高，心率降低。脊髓横断可预防L-谷氨酸诱导的高血压，而阿托品（1毫克/千克静脉注射）预处理可逆转心动过缓。静脉注射和向脑池内注射L-谷氨酸时，也可使平均动脉压呈剂量依赖性升高，但剂量-效应曲线右移。最后，六甲铵（30毫克/千克静脉注射）预处理可消除静脉注射L-谷氨酸所致的高血压。这些数据表明，孤束核可能在L-谷氨酸的中枢升压效应中起决定性作用。此外，我们证明这种高血压是由于中枢交感神经兴奋所致，自主神经系统也介导了静脉注射L-谷氨酸的升压效应。
