Handal Regeen, Qunibi Lulu, Sahouri Ibrahim, Juhari Maha, Dawodi Rula, Marzouqa Hiyam, Hindiyeh Musa
Caritas Baby Hospital, Bethlehem, State of Palestine.
Bethlehem University, Bethlehem, State of Palestine.
Int J Microbiol. 2017;2017:8012104. doi: 10.1155/2017/8012104. Epub 2017 Jul 26.
The American Centers for Disease Control and Prevention (CDC) recognizes as a source of global outbreaks and epidemics especially due to its increasing resistance to commercially available antibiotics. In this study, 69 single patient multidrug resistant isolates collected from all over Palestine, except Gaza, were studied. All the isolates were resistant to all the -lactam antibiotics including the carbapenems. Of the 69 isolates, 82.6% were positive for , 14.5% were positive for , and 3% were positive for . None were positive for and . In addition, 5.8% and 0% were positive for and , respectively. Of the 69 isolates, none were positive for the aminoglycoside gene while 93% were positive for the gene. The acetyltransferases and genes tested positive in 22% and 13% of the isolates, respectively. The biofilm-producing virulence gene was detected in all isolates. Finally, Multilocus Sequence Typing (MLST) of 13 isolates revealed that more than one strain of was circulating in Palestinian hospitals as results revealed that 7 isolates were of ST208, 2 isolates ST218, 1 isolate ST231, 1 isolate ST348, and 2 new Sequence Types. The detection of these drug resistant pathogens is a reminder of the importance of active surveillance for resistant bacteria in order to prevent their spread in hospital settings.
美国疾病控制与预防中心（CDC）认识到……是全球疫情爆发的一个源头，特别是由于其对市售抗生素的耐药性不断增强。在本研究中，对从巴勒斯坦全境（除加沙外）收集的69株单患者多重耐药菌株进行了研究。所有分离株对包括碳青霉烯类在内的所有β-内酰胺类抗生素均耐药。在这69株分离株中，82.6%的……呈阳性，14.5%的……呈阳性，3%的……呈阳性。……和……均无阳性。此外，……和……的阳性率分别为5.8%和0%。在69株分离株中，氨基糖苷类……基因均无阳性，而93%的……基因呈阳性。乙酰转移酶……和……基因分别在22%和13%的分离株中检测呈阳性。所有分离株中均检测到生物膜产生毒力基因。最后，对13株分离株进行多位点序列分型（MLST）显示，巴勒斯坦医院中有不止一种……菌株在传播，结果显示7株为ST208型，2株为ST218型，1株为ST231型，1株为ST348型，还有2种新的序列类型。这些耐药病原体的检测提醒人们，积极监测耐药细菌对于防止其在医院环境中传播非常重要。
需注意，原文中部分内容缺失关键信息，翻译时用“……”替代，可能会影响对完整内容的理解。
