埃及鲍曼不动杆菌临床分离株中bla(NDM-1)碳青霉烯酶编码基因和16S rRNA armA甲基转移酶基因的高流行率。
High prevalence of bla(NDM-1) carbapenemase-encoding gene and 16S rRNA armA methyltransferase gene among Acinetobacter baumannii clinical Isolates in Egypt.
作者信息
El-Sayed-Ahmed Mohamed Abd El-Gawad, Amin Magdy Ali, Tawakol Wael Mustafa, Loucif Lotfi, Bakour Sofiane, Rolain Jean-Marc
机构信息
Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France Department of Microbiology and Immunology, Faculty of Pharmacy, Misr University for Science and Technology (MUST), Cairo, Egypt.
Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
出版信息
Antimicrob Agents Chemother. 2015;59(6):3602-5. doi: 10.1128/AAC.04412-14. Epub 2015 Mar 23.
Abstract
The main objective of this study was to decipher the molecular mechanism of resistance to carbapenems and aminoglycosides in a large series of 150 Acinetobacter baumannii clinical isolates collected from July 2012 to September 2013 in Egypt. We report for the first time the emergence of bla(NDM-1) and the cooccurrence of 16S rRNA methylase armA with bla(NDM-1) and bla(OXA-23) in Egyptian hospitals. Multilocus sequence typing identified 27 distinct sequence types, 11 of which were novel.
摘要
本研究的主要目的是解读2012年7月至2013年9月在埃及收集的150株鲍曼不动杆菌临床分离株对碳青霉烯类和氨基糖苷类耐药的分子机制。我们首次报告了bla(NDM-1)在埃及医院的出现，以及16S rRNA甲基化酶armA与bla(NDM-1)和bla(OXA-23)的共同存在。多位点序列分型确定了27种不同的序列类型，其中11种是新的。
相似文献
1
High prevalence of bla(NDM-1) carbapenemase-encoding gene and 16S rRNA armA methyltransferase gene among Acinetobacter baumannii clinical Isolates in Egypt.埃及鲍曼不动杆菌临床分离株中bla(NDM-1)碳青霉烯酶编码基因和16S rRNA armA甲基转移酶基因的高流行率。
Antimicrob Agents Chemother. 2015;59(6):3602-5. doi: 10.1128/AAC.04412-14. Epub 2015 Mar 23.
2
Characterization of Acinetobacter baumannii clinical isolates carrying bla(OXA-23) carbapenemase and 16S rRNA methylase armA genes in Yemen.也门携带bla(OXA-23)碳青霉烯酶和16S rRNA甲基化酶armA基因的鲍曼不动杆菌临床分离株的特征分析
Microb Drug Resist. 2014 Dec;20(6):604-9. doi: 10.1089/mdr.2014.0018.
3
Prevalence of 16S rRNA methylase, modifying enzyme, and extended-spectrum beta-lactamase genes among Acinetobacter baumannii isolates.鲍曼不动杆菌分离株中16S rRNA甲基化酶、修饰酶和超广谱β-内酰胺酶基因的流行情况。
J Chemother. 2015 Aug;27(4):207-12. doi: 10.1179/1973947814Y.0000000190. Epub 2014 Apr 27.
4
First report of 16S rRNA methylase ArmA-producing Acinetobacter baumannii and rapid spread of metallo-β-lactamase NDM-1 in Algerian hospitals.产16S rRNA甲基化酶ArmA的鲍曼不动杆菌的首次报道及金属β-内酰胺酶NDM-1在阿尔及利亚医院的快速传播。
J Infect Chemother. 2014 Nov;20(11):696-701. doi: 10.1016/j.jiac.2014.07.010. Epub 2014 Sep 16.
5
Dissemination of clonal complex 2 Acinetobacter baumannii strains co-producing carbapenemases and 16S rRNA methylase ArmA in Vietnam.越南产碳青霉烯酶和16S rRNA甲基化酶ArmA的克隆复合体2鲍曼不动杆菌菌株的传播。
BMC Infect Dis. 2015 Oct 15;15:433. doi: 10.1186/s12879-015-1171-x.
6
Emergence of a multidrug-resistant plasmid encoding , and in a clinical isolate of in Japan.在日本的一株临床分离株中发现了一种携带 、 和 的多药耐药质粒。
J Med Microbiol. 2021 Aug;70(8). doi: 10.1099/jmm.0.001395.
7
Dissemination of International Clone II Strains Coproducing OXA-23 Carbapenemase and 16S rRNA Methylase ArmA in Athens, Greece.希腊雅典地区同时产生 OXA-23 碳青霉烯酶和 16S rRNA 甲基化酶 ArmA 的国际克隆 II 株的传播。
Microb Drug Resist. 2020 Jan;26(1):9-13. doi: 10.1089/mdr.2019.0075. Epub 2019 Aug 8.
8
Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North America.北美地区产16S rRNA甲基化酶鲍曼不动杆菌临床菌株的鉴定
Antimicrob Agents Chemother. 2007 Nov;51(11):4209-10. doi: 10.1128/AAC.00560-07. Epub 2007 Sep 4.
9
[Study on carbapenemase and 16S rRNA methylase of imipenem-resistant Acinetobacter baumannii].耐亚胺培南鲍曼不动杆菌碳青霉烯酶及16S rRNA甲基化酶的研究
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Mar;30(3):269-72.
10
Molecular epidemiology of Acinetobacter baumannii in different hospitals in Tripoli, Lebanon using bla(OXA-51-like) sequence based typing.使用基于bla(OXA - 51样)序列分型法对黎巴嫩的黎波里不同医院鲍曼不动杆菌进行分子流行病学研究
BMC Microbiol. 2015 May 16;15:103. doi: 10.1186/s12866-015-0441-5.
引用本文的文献
1
Comparative genomics of Acinetobacter baumannii from Egyptian healthcare settings reveals high-risk clones and resistance gene mobilization.来自埃及医疗机构的鲍曼不动杆菌比较基因组学揭示了高风险克隆和耐药基因的转移。
BMC Infect Dis. 2025 Jun 11;25(1):803. doi: 10.1186/s12879-025-11185-x.
2
Emergence of NDM-1- and OXA-23-Co-Producing ST1 Isolates from a Burn Unit in Spain.西班牙一家烧伤病房中同时产生NDM-1和OXA-23的ST1菌株的出现。
Microorganisms. 2025 May 16;13(5):1149. doi: 10.3390/microorganisms13051149.
3
Genetic profiling of multidrug-resistant from a tertiary care center in Malaysia.马来西亚一家三级护理中心耐多药菌的基因分型
Microbiol Spectr. 2025 Feb 4;13(2):e0087224. doi: 10.1128/spectrum.00872-24. Epub 2024 Dec 20.
4
Global Clone-Specific Resistomes Explored in Clinical Isolates Recovered from Egypt.在从埃及分离出的临床菌株中探索全球特定克隆的耐药基因组。
Antibiotics (Basel). 2023 Jul 4;12(7):1149. doi: 10.3390/antibiotics12071149.
5
Clinical and molecular features of NDM-producing Acinetobacter baumannii in a multicenter study in Israel.在以色列的一项多中心研究中，产 NDM 鲍曼不动杆菌的临床和分子特征。
Ann Clin Microbiol Antimicrob. 2023 Jun 30;22(1):52. doi: 10.1186/s12941-023-00607-w.
6
Ribosome-targeting antibiotics and resistance ribosomal RNA methylation.靶向核糖体的抗生素与核糖体RNA甲基化抗性
RSC Med Chem. 2023 Mar 1;14(4):624-643. doi: 10.1039/d2md00459c. eCollection 2023 Apr 26.
7
Multidrug-Resistant Infections in the United Kingdom versus Egypt: Trends and Potential Natural Products Solutions.英国与埃及的多重耐药感染：趋势与潜在的天然产物解决方案
Antibiotics (Basel). 2023 Jan 1;12(1):77. doi: 10.3390/antibiotics12010077.
8
Prevalence and Phenotypic and Molecular Characterization of Carbapenemase-Producing Gram-Negative Bacteria in Gabon.加蓬产碳青霉烯酶革兰氏阴性菌的流行情况及表型和分子特征。
Am J Trop Med Hyg. 2022 Dec 19;108(2):268-274. doi: 10.4269/ajtmh.22-0168. Print 2023 Feb 1.
9
Genomic Analysis of a Strain Collection Containing Multidrug-, Extensively Drug-, Pandrug-, and Carbapenem-Resistant Modern Clinical Isolates of Acinetobacter baumannii.一株包含多重耐药、广泛耐药、泛耐药和碳青霉烯类耐药的鲍曼不动杆菌现代临床分离株的基因组分析。
Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0089222. doi: 10.1128/aac.00892-22. Epub 2022 Aug 15.
10
Genetic Configuration of Genomic Resistance Islands in Clinical Isolates From Egypt.埃及临床分离株中基因组抗性岛的遗传结构
Front Microbiol. 2022 Jul 22;13:878912. doi: 10.3389/fmicb.2022.878912. eCollection 2022.
本文引用的文献
1
Epidemiological characteristics of blaNDM-1 in Enterobacteriaceae and the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in China from 2011 to 2012.2011年至2012年中国肠杆菌科细菌及醋酸钙不动杆菌-鲍曼不动杆菌复合体中blaNDM-1的流行病学特征
PLoS One. 2014 Dec 3;9(12):e113852. doi: 10.1371/journal.pone.0113852. eCollection 2014.
2
Epidemic diffusion of OXA-23-producing Acinetobacter baumannii isolates in Italy: results of the first cross-sectional countrywide survey.意大利产OXA-23鲍曼不动杆菌菌株的流行扩散：首次全国性横断面调查结果
J Clin Microbiol. 2014 Aug;52(8):3004-10. doi: 10.1128/JCM.00291-14. Epub 2014 Jun 11.
3
Characterization of carbapenem-resistant Acinetobacter baumannii in Brazil (2008-2011): countrywide spread of OXA-23-producing clones (CC15 and CC79).巴西耐碳青霉烯鲍曼不动杆菌的特征（2008 - 2011年）：产OXA - 23克隆（CC15和CC79）在全国范围的传播。
Diagn Microbiol Infect Dis. 2014 Aug;79(4):468-72. doi: 10.1016/j.diagmicrobio.2014.03.006. Epub 2014 Mar 17.
4
CarbAcineto NP test for rapid detection of carbapenemase-producing Acinetobacter spp.用于快速检测产碳青霉烯酶不动杆菌属的CarbAcineto NP试验
J Clin Microbiol. 2014 Jul;52(7):2359-64. doi: 10.1128/JCM.00594-14. Epub 2014 Apr 23.
5
Molecular characterization of carbapenem-insensitive Acinetobacter baumannii in Egypt.埃及碳青霉烯不敏感鲍曼不动杆菌的分子特征
Int J Infect Dis. 2014 May;22:49-54. doi: 10.1016/j.ijid.2013.12.004. Epub 2014 Mar 4.
6
Emergence of carbapenem-resistant Acinetobacter baumannii harboring the OXA-23 carbapenemase in intensive care units of Egyptian hospitals.产 OXA-23 碳青霉烯酶鲍曼不动杆菌在埃及医院重症监护病房的出现。
Int J Infect Dis. 2013 Dec;17(12):e1252-4. doi: 10.1016/j.ijid.2013.07.012. Epub 2013 Sep 11.
7
Prevalence of carbapenemase-encoding genes including New Delhi metallo-β-lactamase in Acinetobacter species, Algeria.耐碳青霉烯酶基因（包括新德里金属β-内酰胺酶）在阿尔及利亚不动杆菌属中的流行情况。
Int J Infect Dis. 2013 Sep;17(9):e739-43. doi: 10.1016/j.ijid.2013.02.024. Epub 2013 Apr 16.
8
Diversity in Acinetobacter baumannii isolates from paediatric cancer patients in Egypt.埃及儿科癌症患者分离的鲍曼不动杆菌的多样性。
Clin Microbiol Infect. 2013 Nov;19(11):1082-8. doi: 10.1111/1469-0691.12143. Epub 2013 Feb 15.
9
Epidemiology and clonality of carbapenem-resistant Acinetobacter baumannii from an intensive care unit in Palermo, Italy.意大利巴勒莫一家重症监护病房耐碳青霉烯鲍曼不动杆菌的流行病学与克隆性研究
BMC Res Notes. 2012 Jul 20;5:365. doi: 10.1186/1756-0500-5-365.
10
Rapid detection of carbapenem resistance in Acinetobacter baumannii using matrix-assisted laser desorption ionization-time of flight mass spectrometry.利用基质辅助激光解吸电离飞行时间质谱法快速检测鲍曼不动杆菌的碳青霉烯类耐药性。
PLoS One. 2012;7(2):e31676. doi: 10.1371/journal.pone.0031676. Epub 2012 Feb 16.
Zotero 插件