Haddad Jessica M, Chen Elizabeth S
Center for Biomedical Informatics, Brown University, Providence, RI.
AMIA Jt Summits Transl Sci Proc. 2017 Jul 26;2017:502-511. eCollection 2017.
Obstructive sleep apnea (OSA) is one of the most common diseases among Americans, affecting between 5 and 20% of the population. While there is existing evidence of numerous comorbid conditions, such as obesity, diabetes, and high blood pressure, the vast majority of this evidence has focused explicitly on cardiovascular morbidities and excluded any mental or behavioral disorders. The goal of this study was to examine psychiatric comorbidities of OSA in two types of sources: (1) biomedical literature in the MEDLINE/PubMed database (focusing on MeSH descriptors) and Semantic MEDLINE Database (SemMedDB; for semantic predications), and (2) electronic health record data in the MIMIC-III database. Approximately 300 unique psychiatric comorbidities were identified, ranked, and compared across MEDLINE/PubMed, SemMedDB, and MIMIC-III. The preliminary results highlight the potential of this multi-angled approach for suggesting opportunities for further investigation that may contribute to improving mental health in persons afflicted with OSA.
阻塞性睡眠呼吸暂停（OSA）是美国人中最常见的疾病之一，影响着5%至20%的人口。虽然有大量关于多种合并症的现有证据，如肥胖、糖尿病和高血压，但绝大多数此类证据明确聚焦于心血管疾病，并未包括任何精神或行为障碍。本研究的目的是在两种来源中检查OSA的精神合并症：（1）MEDLINE/PubMed数据库中的生物医学文献（侧重于医学主题词描述符）和语义MEDLINE数据库（SemMedDB；用于语义预测），以及（2）MIMIC-III数据库中的电子健康记录数据。在MEDLINE/PubMed、SemMedDB和MIMIC-III中识别、排名并比较了约300种独特的精神合并症。初步结果凸显了这种多角度方法在为进一步研究提供机会方面的潜力，这些研究可能有助于改善OSA患者的心理健康。
