第三代抗惊厥药物的药理学与毒理学
The Pharmacology and Toxicology of Third-Generation Anticonvulsant Drugs.
作者信息
LaPenna Paul, Tormoehlen Laura M
机构信息
Department of Neurology, Indiana University, 355 W. 16th Street, Suite 3200, Indianapolis, IN, 46202, USA.
Department of Emergency Medicine, Indiana University, Indianapolis, IN, USA.
出版信息
J Med Toxicol. 2017 Dec;13(4):329-342. doi: 10.1007/s13181-017-0626-4. Epub 2017 Aug 16.
Epilepsy is a neurologic disorder affecting approximately 50 million people worldwide, or about 0.7% of the population [1]. Thus, the use of anticonvulsant drugs in the treatment of epilepsy is common and widespread. There are three generations of anticonvulsant drugs, categorized by the year in which they were developed and released. The aim of this review is to discuss the pharmacokinetics, drug-drug interactions, and adverse events of the third generation of anticonvulsant drugs. Where available, overdose data will be included. The pharmacokinetic properties of third-generation anticonvulsant drugs include relatively fewer drug-drug interactions, as well as several unique and life-threatening adverse events. Overdose data are limited, so thorough review of adverse events and knowledge of drug mechanism will guide expectant management of future overdose cases. Reporting of these cases as they occur will be necessary to further clarify toxicity of these drugs.
癫痫是一种神经系统疾病，全球约有5000万人受其影响，约占总人口的0.7%[1]。因此，抗惊厥药物在癫痫治疗中的应用很常见且广泛。抗惊厥药物有三代，根据其研发和上市年份分类。本综述的目的是讨论第三代抗惊厥药物的药代动力学、药物相互作用和不良事件。如有可用的过量用药数据也将纳入。第三代抗惊厥药物的药代动力学特性包括相对较少的药物相互作用，以及一些独特且危及生命的不良事件。过量用药数据有限，因此对不良事件的全面审查和药物作用机制的了解将指导未来过量用药病例的预期管理。在这些病例发生时进行报告对于进一步阐明这些药物的毒性是必要的。
Zotero 插件