Kerkhofs Martijn, Giorgi Carlotta, Marchi Saverio, Seitaj Bruno, Parys Jan B, Pinton Paolo, Bultynck Geert, Bittremieux Mart
Laboratory Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut (LKI), KU Leuven, Campus Gasthuisberg O&N 1 Box 802, Herestraat 49, 3000, Leuven, Belgium.
Laboratory for Technologies of Advanced Therapies (LTTA), Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, Italy.
Adv Exp Med Biol. 2017;997:225-254. doi: 10.1007/978-981-10-4567-7_17.
Inter-organellar contact sites establish microdomains for localised Ca-signalling events. One of these microdomains is established between the ER and the mitochondria. Importantly, the so-called mitochondria-associated ER membranes (MAMs) contain, besides structural proteins and proteins involved in lipid exchange, several Ca-transport systems, mediating efficient Ca transfer from the ER to the mitochondria. These Ca signals critically control several mitochondrial functions, thereby impacting cell metabolism, cell death and survival, proliferation and migration. Hence, the MAMs have emerged as critical signalling hubs in physiology, while their dysregulation is an important factor that drives or at least contributes to oncogenesis and tumour progression. In this book chapter, we will provide an overview of the role of the MAMs in cell function and how alterations in the MAM composition contribute to oncogenic features and behaviours.
细胞器间接触位点为局部钙信号事件建立微区。其中一个微区在内质网（ER）和线粒体之间形成。重要的是，所谓的线粒体相关内质网膜（MAMs）除了含有结构蛋白和参与脂质交换的蛋白外，还包含几种钙转运系统，介导钙从内质网到线粒体的高效转移。这些钙信号严格控制多种线粒体功能，从而影响细胞代谢、细胞死亡与存活、增殖和迁移。因此，MAMs已成为生理学中关键的信号枢纽，而其失调是驱动或至少促成肿瘤发生和肿瘤进展的重要因素。在本章中，我们将概述MAMs在细胞功能中的作用，以及MAM组成的改变如何导致致癌特征和行为。
