Department of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, Rzeszow, Poland.
Lab for Molecular and Cellular Signalling, Department for Cellular and Molecular Medicine, Leuven Kanker Instituut, KU Leuven, Leuven, Belgium.
Cell Mol Life Sci. 2021 Oct;78(19-20):6541-6556. doi: 10.1007/s00018-021-03920-9. Epub 2021 Aug 27.
Membrane-contact sites are getting more and more credit for their indispensable role in maintenance of cell function and homeostasis. In the last decades, the ER-mitochondrial contact sites in particular received a lot of attention. While our knowledge of ER-mitochondrial contact sites increases steadily, the focus often lies on a static exploration of their functions. However, it is increasingly clear that these contact sites are very dynamic. In this review, we highlight the dynamic nature of ER-mitochondrial contact sites and the role of kinases and phosphatases therein with a focus on recent findings. Phosphorylation events allow for rapid integration of information on the protein level, impacting protein function, localization and interaction at ER-mitochondrial contact sites. To illustrate the importance of these events and to put them in a broader perspective, we connect them to pathologies like diabetes type II, Parkinson's disease and cancer.
膜接触位点在维持细胞功能和动态平衡方面的不可或缺的作用越来越受到重视。在过去的几十年中，内质网-线粒体接触位点尤其受到关注。虽然我们对内质网-线粒体接触位点的了解在稳步增加，但重点往往放在对其功能的静态探索上。然而，越来越明显的是，这些接触位点是非常动态的。在这篇综述中，我们强调了内质网-线粒体接触位点的动态性质以及其中激酶和磷酸酶的作用，重点介绍了最近的发现。磷酸化事件允许在蛋白质水平上快速整合信息，影响内质网-线粒体接触位点的蛋白质功能、定位和相互作用。为了说明这些事件的重要性，并将它们置于更广泛的背景下，我们将它们与 II 型糖尿病、帕金森病和癌症等疾病联系起来。
