Zharkovskiĭ A M, Langel Iu L, Chereshka K S, Zharkovskaia T A
Biull Eksp Biol Med. 1987 Mar;103(3):317-9.
In experiments on rats and mice the correlation between the ability of neuroleptics to antagonize apomorphine induced stereotypy and to block central dopamine and muscarinic acetylcholine receptors was studied. The analysis showed significant correlation (v = 0.76; P less than 0.05) between antistereotypic effects of drugs and their ability to inhibit 3H-spiperone binding to rat striated tissue. However, no correlation was found between antistereotypic effect of neuroleptics and their ability to block 3H-quinuclidinyl benzylate binding or arecoline-induced tremor.
在对大鼠和小鼠的实验中，研究了抗精神病药物拮抗阿扑吗啡诱导的刻板行为以及阻断中枢多巴胺和毒蕈碱型乙酰胆碱受体的能力之间的相关性。分析表明，药物的抗刻板行为作用与其抑制3H-螺哌隆与大鼠纹状组织结合的能力之间存在显著相关性（v = 0.76；P < 0.05）。然而，未发现抗精神病药物的抗刻板行为作用与其阻断3H-喹核醇基苯甲酸酯结合或槟榔碱诱导的震颤的能力之间存在相关性。
