Bertoin P, Dutou L, Lacroze M, Bailly C
Rev Stomatol Chir Maxillofac. 1979;80(3):166-9.
About 10% of patients developed severe sequelae following radiotherapy, which had been associated with surgical treatment, even though they were, or appeared to be cured. Complications affected the skin and soft tissues (causing skin retraction, loss of substance, and sometimes trismus) and bone (necrosis required surgical treatment, and when there was associated cutaneous dystrophy, resulted in exposure of the bone and severe functional and esthetic problems). A critical study of the radiotherapeutic techniques used suggests that the dose given should be reduced, the fields modified, and Cobalt used in preference to electrons in most cases.
约10%的患者在放疗后出现严重后遗症,这些后遗症与手术治疗有关,尽管他们当时已治愈或看似已治愈。并发症影响皮肤和软组织(导致皮肤回缩、组织缺失,有时出现牙关紧闭)以及骨骼(坏死需要手术治疗,若伴有皮肤营养不良,则会导致骨质外露以及严重的功能和美观问题)。对所采用放疗技术的批判性研究表明,应降低放疗剂量、调整照射野,并且在大多数情况下优先使用钴而非电子进行放疗。