Kutzner J, Heinrich H G, Draf W
HNO. 1978 Aug;26(8):253-7.
From 1966--1974, 628 patients were irradiated with Cobalt-60 as treatment for tumors of the head and neck. Tumor doses ranged from 6200 R to 8000 R. An osteoradionecrosis was discovered in 17 patients, and was mostly localized in the mandible. Most of the patients developed the necrosis during the first two years following completion of their radiation, although necrosis was also found up to 9 years following therapy. Prophylactic treatment of teeth should be completed before beginning radiation therapy, but such does not exclude the risk of necrosis.
1966年至1974年期间,628例头颈部肿瘤患者接受了钴-60照射治疗。肿瘤剂量范围为6200拉德至8000拉德。17例患者发生了放射性骨坏死,主要位于下颌骨。大多数患者在放疗结束后的头两年内出现坏死,不过在治疗后长达9年也发现有坏死情况。牙齿的预防性治疗应在开始放疗前完成,但这并不能排除坏死的风险。