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处方数据库研究中的睾酮治疗与心血管事件

Testosterone treatment and cardiovascular events in prescription database studies.

作者信息

Shores Molly M

机构信息

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, VA Puget Sound Health Care System, 1660 South Columbian Way Seattle, WA 98108, USA.

出版信息

Asian J Androl. 2018 Mar-Apr;20(2):138-144. doi: 10.4103/aja.aja_25_17.

DOI:10.4103/aja.aja_25_17
PMID:28816202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5858096/
Abstract

Over the past decade, there has been a substantial increase in the number of men who are treated with testosterone. Despite this increase in the use of testosterone, the risks of adverse cardiovascular events are unclear as meta-analyses have reported conflicting findings and no clinical studies have been large enough or long enough to adequately assess for cardiovascular risks. The goal of this paper is to review large prescription database studies of testosterone treatment and adverse cardiovascular events and mortality with the aim of providing some guidance for clinicians and researchers in this controversial area.

摘要

在过去十年中,接受睾酮治疗的男性人数大幅增加。尽管睾酮的使用有所增加,但不良心血管事件的风险尚不清楚,因为荟萃分析报告的结果相互矛盾,而且没有足够大或足够长的临床研究来充分评估心血管风险。本文的目的是回顾关于睾酮治疗以及不良心血管事件和死亡率的大型处方数据库研究,旨在为这一有争议领域的临床医生和研究人员提供一些指导。

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本文引用的文献

1
Testosterone treatment and risk of venous thromboembolism: population based case-control study.睾酮治疗与静脉血栓栓塞风险:基于人群的病例对照研究。
BMJ. 2016 Nov 30;355:i5968. doi: 10.1136/bmj.i5968.
2
Association Between Testosterone Replacement Therapy and the Incidence of DVT and Pulmonary Embolism: A Retrospective Cohort Study of the Veterans Administration Database.睾酮替代疗法与深静脉血栓形成和肺栓塞发生率的关联:退伍军人管理局数据库的回顾性队列研究。
Chest. 2016 Sep;150(3):563-71. doi: 10.1016/j.chest.2016.05.007. Epub 2016 May 12.
3
Survival and cardiovascular events in men treated with testosterone replacement therapy: an intention-to-treat observational cohort study.接受睾酮替代治疗的男性的生存和心血管事件:一项意向治疗观察性队列研究。
Lancet Diabetes Endocrinol. 2016 Jun;4(6):498-506. doi: 10.1016/S2213-8587(16)00112-1. Epub 2016 May 7.
4
Impact of Testosterone Replacement Therapy on Myocardial Infarction, Stroke, and Death in Men With Low Testosterone Concentrations in an Integrated Health Care System.在一个综合医疗保健系统中,睾酮替代疗法对睾酮浓度低的男性发生心肌梗死、中风和死亡的影响。
Am J Cardiol. 2016 Mar 1;117(5):794-9. doi: 10.1016/j.amjcard.2015.11.063. Epub 2015 Dec 13.
5
Association between Use of Exogenous Testosterone Therapy and Risk of Venous Thrombotic Events among Exogenous Testosterone Treated and Untreated Men with Hypogonadism.雄激素治疗的男性与未治疗的男性中,外源性睾丸激素治疗与静脉血栓栓塞事件风险的关系。
J Urol. 2016 Apr;195(4 Pt 1):1065-72. doi: 10.1016/j.juro.2015.10.134. Epub 2015 Oct 31.
6
Association Between Testosterone Supplementation Therapy and Thrombotic Events in Elderly Men.老年男性睾酮补充治疗与血栓形成事件之间的关联
Urology. 2015 Aug;86(2):283-5. doi: 10.1016/j.urology.2015.03.049.
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Re: Testosterone Products: Drug Safety Communication - FDA Cautions about Using Testosterone Products for Low Testosterone due to Aging; Requires Labeling Change to Inform of Possible Increased Risk of Heart Attack and Stroke.主题:睾酮产品:药品安全通讯 - 美国食品药品监督管理局就因衰老导致睾酮水平低而使用睾酮产品发出警示;要求更改标签以告知心脏病发作和中风风险可能增加的情况。
J Urol. 2015 Sep;194(3):759-60. doi: 10.1016/j.juro.2015.06.058. Epub 2015 Jun 18.
8
Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men.睾酮水平正常化与男性心肌梗死和死亡率的降低有关。
Eur Heart J. 2015 Oct 21;36(40):2706-15. doi: 10.1093/eurheartj/ehv346. Epub 2015 Aug 6.
9
Risk of Venous Thromboembolism in Men Receiving Testosterone Therapy.男性接受睾酮治疗的静脉血栓栓塞风险。
Mayo Clin Proc. 2015 Aug;90(8):1038-45. doi: 10.1016/j.mayocp.2015.05.012. Epub 2015 Jul 20.
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Myocardial Infarction and Stroke Risk in Young Healthy Men Treated with Injectable Testosterone.接受注射用睾酮治疗的年轻健康男性的心肌梗死和中风风险
Int J Endocrinol. 2015;2015:970750. doi: 10.1155/2015/970750. Epub 2015 Jun 1.