Zhong Shang-Rong, Yang Han-Hsuan, Liao Cheng-Hsi, Yang Deng-Ho, Tu Shih-Kai, Hung Chia-Lien, Liao Chun-Cheng
Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan.
Department of Occupational Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Diabetes Metab Syndr Obes. 2021 Jan 11;14:99-106. doi: 10.2147/DMSO.S282832. eCollection 2021.
To assess the association between serum testosterone (T) and metabolic syndrome (MS) in different age groups in Taiwanese men.
Male participants, regardless of age or any underlying disease, were identified from MJ Health Screening Center in Taiwan from 2007 to 2016 for this cross-sectional study. They were divided into three groups according to age, and further classified according to MS diagnosis. Basic patient characteristics with relevant parameters were obtained. One-way ANOVA of mean T values between different numbers of measures that exceeds the cut-off values of MS components was performed to assess the relationship of T and MS. Logistic regression analysis was also used to estimate the risk for MS with each increment in T, age, and BMI.
A total of 4,931 men were included. The MS group had significantly lower serum T levels compared to the non-MS group in each age group. The one-way ANOVA found the mean value of T was significantly higher in patients without MS component (6.19±2.12 ng/mL) than those with 1-5 MS components (with one MS component: 5.48±2.13 ng/mL, two MS components: 4.93±2.03 ng/mL, three MS components: 4.37±1.60 ng/mL, four MS components: 4.13±2.89 ng/mL, five MS components: 3.74±1.27 ng/mL, and <0.001). There was no significant difference between the patients with three components and the patients with four or five components. Logistic regression models with age stratification showed T with lower odds ratio (OR) for MS after adjusting for BMI in those ≥65 years old (OR=0.693; 95% CI=0.559-0.858; <0.001); 50-64 years old (OR=0.868; 95% CI=0.802-0.940; <0.001) and <50 years old (OR=0.810; 95% CI=0.758-0.865; <0.001).
Lower serum T was strongly associated with MS, with the predictive value increasing with age in Taiwanese men.
评估台湾男性不同年龄组血清睾酮（T）与代谢综合征（MS）之间的关联。
本横断面研究从2007年至2016年在台湾的MJ健康筛查中心招募男性参与者，无论其年龄或任何潜在疾病。根据年龄将他们分为三组，并根据MS诊断进一步分类。获取患者的基本特征及相关参数。对超过MS组分临界值的不同数量指标之间的平均T值进行单因素方差分析，以评估T与MS的关系。还使用逻辑回归分析来估计随着T、年龄和BMI的每一次增加患MS的风险。
共纳入4931名男性。在每个年龄组中，MS组的血清T水平均显著低于非MS组。单因素方差分析发现，无MS组分的患者T平均值（6.19±2.12 ng/mL）显著高于有1 - 5个MS组分的患者（有一个MS组分：5.48±2.13 ng/mL，两个MS组分：4.93±2.03 ng/mL，三个MS组分：4.37±1.60 ng/mL，四个MS组分：4.13±2.89 ng/mL，五个MS组分：3.74±1.27 ng/mL，P<0.001）。有三个组分的患者与有四个或五个组分的患者之间无显著差异。年龄分层的逻辑回归模型显示，在≥65岁（OR = 0.693；95% CI = 0.559 - 0.858；P<0.001）、50 - 64岁（OR = 0.868；95% CI = 0.802 - 0.940；P<0.001）和<50岁（OR = 0.810；95% CI = 0.758 - 0.865；P<0.001）的人群中，调整BMI后，T与MS的比值比（OR）较低。
较低的血清T与MS密切相关，在台湾男性中，其预测价值随年龄增加而增加。
