生长抑素对大鼠小肠中D-半乳糖转运的影响。

Effect of somatostatin on D-galactose transport across the small intestine of rats.

作者信息

Sorribas V, Arruebo P, Murillo D, Alcalde A I

出版信息

Comp Biochem Physiol A Comp Physiol. 1987;86(1):63-6. doi: 10.1016/0300-9629(87)90277-5.

Abstract

Somatostatin was found to diminish control and theophylline-treated tissue sugar accumulation as well as control and also to diminish theophylline mucosal to serosal D-galactose fluxes. When Na+ was removed from the bath solution, sugar transport was unaltered by the presence of somatostatin. The same results were obtained with phlorizin in the medium. These results seem to suggest that the action of somatostatin is restricted to the Na+-dependent sugar carrier located on the brush border of the intestinal epithelium.

摘要

研究发现，生长抑素可减少对照组及茶碱处理组组织的糖积累，同时也可减少对照组及茶碱处理组黏膜到浆膜的D-半乳糖通量。当从浴液中去除Na+时，生长抑素的存在并未改变糖转运。在培养基中加入根皮苷也得到了相同的结果。这些结果似乎表明，生长抑素的作用仅限于位于肠上皮刷状缘的Na+依赖性糖载体。