Radzeviciene Lina, Ostrauskas Rytas
a Institute of Endocrinology, Medical Academy , Lithuanian University of Health Sciences , Kaunas , Lithuania.
Women Health. 2018 Sep;58(8):884-897. doi: 10.1080/03630242.2017.1358794. Epub 2017 Sep 6.
The purpose of this case-control study was to evaluate the relationship between smoking and type 2 diabetes mellitus (T2DM) in adult females. A total of 168 women in Kaunas, Lithuania with newly diagnosed T2DM during the year 2001 and 336 controls who were women without diabetes were recruited. Participants were asked about their duration of smoking, the number of cigarettes smoked per day, pack-years, and smoking cessation. Odds ratios (OR), 95 percent confidence intervals (CI) for T2DM were calculated using conditional logistic regression. After adjustment for possible confounders, women with T2DM had a nearly threefold higher odds for smoking 10 or more cigarettes per day compared with controls and using never smokers as the referent category (OR = 2.8; 95 percent CI 1.0-7.7). Women with T2DM had over fourfold odds for having smoked for 40 years or more compared to controls (OR = 4.6; 95 percent CI 1.1-18.6). Compared to controls, women with T2DM had over a sixfold higher odds for stopping smoking for 19 or fewer years with never smokers as the referent category (OR = 6.4; 95 percent CI 1.5-27.3). The findings of our study suggest a possible relationship between smoking and T2DM in women. Also, despite smoking cessation, the association with T2DM remained for a long time.
这项病例对照研究的目的是评估成年女性吸烟与2型糖尿病（T2DM）之间的关系。在立陶宛考纳斯，共招募了168名在2001年新诊断为T2DM的女性以及336名无糖尿病的女性作为对照。研究人员询问了参与者的吸烟时长、每日吸烟量、吸烟包年数以及戒烟情况。使用条件逻辑回归计算T2DM的优势比（OR）和95%置信区间（CI）。在对可能的混杂因素进行调整后，与以从不吸烟者为参照组的对照组相比，患T2DM的女性每天吸烟10支或更多的几率高出近三倍（OR = 2.8；95% CI 1.0 - 7.7）。与对照组相比，患T2DM的女性吸烟40年或更长时间的几率高出四倍多（OR = 4.6；95% CI 1.1 - 18.6）。以从不吸烟者为参照组，与对照组相比，患T2DM的女性戒烟19年或更短时间的几率高出六倍多（OR = 6.4；95% CI 1.5 - 27.3）。我们的研究结果表明女性吸烟与T2DM之间可能存在关联。此外，尽管戒烟了，但与T2DM的关联仍持续了很长时间。
