Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania.
Public Health Nutr. 2012 Aug;15(8):1437-41. doi: 10.1017/S1368980012000614. Epub 2012 Mar 6.
Type 2 diabetes mellitus appears to involve an interaction between susceptible genetic backgrounds and environmental factors including highly calorific diets. As it is important to identify modifiable risk factors that may help reduce the risk of type 2 diabetes mellitus, the aim of the present study was to determine the association between egg consumption and the risk of type 2 diabetes mellitus.
A specifically designed questionnaire was used to collect information on possible risk factors of type 2 diabetes mellitus. The odds ratios and 95 % confidence intervals for type 2 diabetes mellitus were calculated by conditional logistic regression.
A case-control study in a Lithuanian out-patient clinic was performed in 2001.
A total of 234 cases with a newly confirmed diagnosis of type 2 diabetes mellitus and 468 controls free of the disease.
Variables such as BMI, family history of diabetes, cigarette smoking, education, morning exercise and plasma TAG level were retained in multivariate logistic regression models as confounders because their inclusion changed the value of the odds ratio by more than 10 % in any exposure category. After adjustment for possible confounders more than twofold increased risk of type 2 diabetes mellitus was determined for individuals consuming 3-4·9 eggs/week (OR = 2·60; 95 % CI 1·34, 5·08) and threefold increased risk of the disease was determined for individuals consuming ≥5 eggs/week (OR = 3·02; 95 % CI 1·14, 7·98) compared with those eating <1 egg/week.
Our data support a possible relationship of egg consumption and increased risk of type 2 diabetes mellitus.
2 型糖尿病似乎涉及易感遗传背景与环境因素（包括高热量饮食）之间的相互作用。由于确定可能有助于降低 2 型糖尿病风险的可改变危险因素非常重要，因此本研究旨在确定鸡蛋摄入量与 2 型糖尿病风险之间的关联。
使用专门设计的问卷收集 2 型糖尿病可能危险因素的信息。使用条件逻辑回归计算 2 型糖尿病的比值比和 95%置信区间。
2001 年在立陶宛门诊诊所进行了病例对照研究。
共纳入 234 例新确诊的 2 型糖尿病患者和 468 例无疾病对照者。
BMI、糖尿病家族史、吸烟、教育程度、晨练和血浆 TAG 水平等变量在多变量逻辑回归模型中被保留为混杂因素，因为它们的纳入使任何暴露类别的比值比发生了 10%以上的变化。在调整了可能的混杂因素后，每周食用 3-4.9 个鸡蛋（OR=2.60；95%CI 1.34，5.08）和每周食用≥5 个鸡蛋（OR=3.02；95%CI 1.14，8.08）的个体患 2 型糖尿病的风险比每周食用<1 个鸡蛋的个体增加了两倍以上。
我们的数据支持鸡蛋摄入量与 2 型糖尿病风险增加之间可能存在关联。
