急性运动后微血管血管舒张可塑性
Microvascular Vasodilator Plasticity After Acute Exercise.
作者信息
Robinson Austin T, Fancher Ibra S, Mahmoud Abeer M, Phillips Shane A
机构信息
Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE.
出版信息
Exerc Sport Sci Rev. 2018 Jan;46(1):48-55. doi: 10.1249/JES.0000000000000130.
Abstract
Endothelium-dependent vasodilation is reduced after acute exercise or after high intraluminal pressure in isolated arterioles from sedentary adults but not in arterioles from regular exercisers. The preserved vasodilation in arterioles from exercisers is hydrogen peroxide (H2O2) dependent, whereas resting dilation is nitric oxide (NO) dependent. We hypothesize chronic exercise elicits adaptations allowing for maintained vasodilation when NO bioavailability is reduced.
摘要
在久坐不动的成年人的离体小动脉中，急性运动后或腔内压力升高后，内皮依赖性血管舒张功能会降低，但经常锻炼者的小动脉则不会。锻炼者小动脉中保留的血管舒张功能依赖于过氧化氢（H2O2），而静息舒张则依赖于一氧化氮（NO）。我们推测，长期运动可引发适应性变化，从而在NO生物利用度降低时维持血管舒张功能。
相似文献
1
Microvascular Vasodilator Plasticity After Acute Exercise.急性运动后微血管血管舒张可塑性
Exerc Sport Sci Rev. 2018 Jan;46(1):48-55. doi: 10.1249/JES.0000000000000130.
2
Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults.急性运动可引起锻炼者而非静坐者的微血管中依赖 H2O2 的血管舒张机制。
Hypertension. 2015 Jan;65(1):140-5. doi: 10.1161/HYPERTENSIONAHA.114.04540. Epub 2014 Nov 3.
3
Exercise and the nitric oxide vasodilator system.运动与一氧化氮血管舒张系统
Sports Med. 2003;33(14):1013-35. doi: 10.2165/00007256-200333140-00001.
4
Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature.运动训练和停训对人体皮肤微血管功能的影响：内皮依赖性舒张在皮肤血管系统中的调节作用。
Eur J Appl Physiol. 2005 Jan;93(4):429-34. doi: 10.1007/s00421-004-1176-4. Epub 2004 Oct 14.
5
Microvascular Adaptations to Exercise: Protective Effect of PGC-1 Alpha.运动诱导的微血管适应性变化：PGC-1α的保护作用。
Am J Hypertens. 2018 Jan 12;31(2):240-246. doi: 10.1093/ajh/hpx162.
6
Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels.白藜芦醇是红酒的一种成分，可引起离体猪视网膜小动脉扩张：一氧化氮和钾通道的作用。
Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4232-9. doi: 10.1167/iovs.07-0094.
7
Nitric oxide and endothelium-dependent hyperpolarization mediated by hydrogen peroxide in health and disease.一氧化氮和过氧化氢介导的内皮依赖性超极化在健康和疾病中的作用。
Basic Clin Pharmacol Toxicol. 2020 Aug;127(2):92-101. doi: 10.1111/bcpt.13377. Epub 2020 Jan 10.
8
Age and exercise training alter signaling through reactive oxygen species in the endothelium of skeletal muscle arterioles.年龄和运动训练会改变骨骼肌小动脉内皮细胞中活性氧物质的信号传递。
J Appl Physiol (1985). 2013 Mar 1;114(5):681-93. doi: 10.1152/japplphysiol.00341.2012. Epub 2013 Jan 3.
9
An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles.管腔内压力的急剧升高会使人体小动脉中血流介导的血管舒张的介质从一氧化氮转变为过氧化氢。
Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1587-93. doi: 10.1152/ajpheart.00557.2014. Epub 2014 Sep 26.
10
Endothelial ATP-sensitive potassium channels mediate coronary microvascular dilation to hyperosmolarity.内皮细胞ATP敏感性钾通道介导冠状动脉微血管对高渗状态的舒张反应。
Am J Physiol. 1997 Jul;273(1 Pt 2):H104-12. doi: 10.1152/ajpheart.1997.273.1.H104.
引用本文的文献
1
Effects of traditional fitness qigong exercise on frailty status and overall well-being in frail or pre-frail patients: a systematic review and meta-analysis.传统健身气功锻炼对虚弱或衰弱前期患者虚弱状况及总体幸福感的影响：一项系统评价与Meta分析
Front Med (Lausanne). 2025 Jul 14;12:1619729. doi: 10.3389/fmed.2025.1619729. eCollection 2025.
2
Examination of post-exercise microvascular reactivity in healthy adults.健康成年人运动后微血管反应性的检测。
Eur J Appl Physiol. 2025 Jul 22. doi: 10.1007/s00421-025-05906-y.
3
Salty Subjects: Unpacking Racial Differences in Salt-Sensitive Hypertension.盐的话题：剖析盐敏感性高血压中的种族差异。
Curr Hypertens Rep. 2024 Jan;26(1):43-58. doi: 10.1007/s11906-023-01275-z. Epub 2023 Oct 25.
4
The damaging duo: Obesity and excess dietary salt contribute to hypertension and cardiovascular disease.这对破坏王：肥胖和过量的膳食盐会导致高血压和心血管疾病。
Obes Rev. 2023 Aug;24(8):e13589. doi: 10.1111/obr.13589. Epub 2023 Jun 19.
5
A single bout of exercise improves vascular insulin sensitivity in adults with obesity.单次运动可改善肥胖成年人的血管胰岛素敏感性。
Obesity (Silver Spring). 2021 Sep;29(9):1487-1496. doi: 10.1002/oby.23229. Epub 2021 Aug 2.
6
Obesity May Not Be Associated with 28-Day Mortality, Duration of Invasive Mechanical Ventilation and Length of Intensive Care Unit and Hospital Stay in Critically Ill Patients with Severe Acute Respiratory Syndrome Coronavirus-2: A Retrospective Cohort Study.肥胖可能与危重症严重急性呼吸综合征冠状病毒 2 感染患者 28 天死亡率、有创机械通气时间、重症监护病房和住院时间无关：一项回顾性队列研究。
Medicina (Kaunas). 2021 Jun 29;57(7):674. doi: 10.3390/medicina57070674.
7
Differential responses of resistance arterioles to elevated intraluminal pressure in blacks and whites.黑人与白人抵抗小动脉对腔内压力升高的差异反应。
Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H29-H37. doi: 10.1152/ajpheart.01023.2020. Epub 2021 May 21.
8
Flavonoids against the Warburg phenotype-concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism.黄酮类化合物对抗瓦博格表型——预测、预防和个性化医学的概念以解开癌细胞代谢的难题
EPMA J. 2020 Jul 30;11(3):377-398. doi: 10.1007/s13167-020-00217-y. eCollection 2020 Sep.
9
Making cell culture more physiological: a call for a more comprehensive assessment of racial disparities in endothelial cell culture studies.使细胞培养更接近生理状态：呼吁更全面地评估内皮细胞培养研究中的种族差异。
Am J Physiol Cell Physiol. 2020 Feb 1;318(2):C238-C241. doi: 10.1152/ajpcell.00467.2019. Epub 2019 Nov 20.
10
The effects of moderate and high-intensity exercise on circulating markers of endothelial integrity and activation in young, healthy men.中等和高强度运动对年轻健康男性循环内皮完整性和激活标志物的影响。
J Appl Physiol (1985). 2019 Nov 1;127(5):1245-1256. doi: 10.1152/japplphysiol.00477.2019. Epub 2019 Sep 5.
本文引用的文献
1
Roles of NADPH oxidase and mitochondria in flow-induced vasodilation of human adipose arterioles: ROS-induced ROS release in coronary artery disease.NADPH氧化酶和线粒体在人体脂肪小动脉血流诱导性血管舒张中的作用：冠状动脉疾病中的活性氧诱导的活性氧释放
Microcirculation. 2017 Aug;24(6). doi: 10.1111/micc.12380.
2
Short-term regular aerobic exercise reduces oxidative stress produced by acute in the adipose microvasculature.短期规律有氧运动可降低急性运动在脂肪组织微血管中产生的氧化应激。
Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H896-H906. doi: 10.1152/ajpheart.00684.2016. Epub 2017 Feb 24.
3
Inwardly rectifying K channels are major contributors to flow-induced vasodilatation in resistance arteries.内向整流钾通道是阻力动脉中血流诱导的血管舒张的主要促成因素。
J Physiol. 2017 Apr 1;595(7):2339-2364. doi: 10.1113/JP273255. Epub 2016 Dec 26.
4
Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes.举重过程中的高血压会降低非运动员的血流介导的血管舒张功能。
Med Sci Sports Exerc. 2017 Apr;49(4):669-675. doi: 10.1249/MSS.0000000000001150.
5
Hyperinsulinemia augments endothelin-1 protein expression and impairs vasodilation of human skeletal muscle arterioles.高胰岛素血症会增加内皮素-1蛋白的表达，并损害人体骨骼肌小动脉的血管舒张功能。
Physiol Rep. 2016 Aug;4(16). doi: 10.14814/phy2.12895. Epub 2016 Aug 22.
6
Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting.久坐引起的腿部内皮功能障碍可通过坐立不安来预防。
Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H177-82. doi: 10.1152/ajpheart.00297.2016. Epub 2016 May 27.
7
Improved arterial flow-mediated dilation after exertion involves hydrogen peroxide in overweight and obese adults following aerobic exercise training.有氧运动训练后，超重和肥胖成年人运动后动脉血流介导的扩张改善涉及过氧化氢。
J Hypertens. 2016 Jul;34(7):1309-16. doi: 10.1097/HJH.0000000000000946.
8
Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress.长时间坐着后出现的内皮功能障碍是由剪切应力降低介导的。
Am J Physiol Heart Circ Physiol. 2016 Mar 1;310(5):H648-53. doi: 10.1152/ajpheart.00943.2015. Epub 2016 Jan 8.
9
Impact of sympathetic nervous system activity on post-exercise flow-mediated dilatation in humans.交感神经系统活动对人体运动后血流介导的血管舒张的影响。
J Physiol. 2015 Dec 1;593(23):5145-56. doi: 10.1113/JP270946. Epub 2015 Nov 15.
10
Shear stress-induced mitochondrial biogenesis decreases the release of microparticles from endothelial cells.剪切应力诱导的线粒体生物合成减少了内皮细胞微粒的释放。
Am J Physiol Heart Circ Physiol. 2015 Aug 1;309(3):H425-33. doi: 10.1152/ajpheart.00438.2014. Epub 2015 May 29.
Zotero 插件