Sebert P, Barthelemy L, Caroff J, Hourmant A
Comp Biochem Physiol A Comp Physiol. 1987;86(3):491-5. doi: 10.1016/0300-9629(87)90531-7.
Nucleotides concentrations (ATP, ADP, AMP) have been measured in brain and muscle of eels exposed to 101 ATA of hydrostatic pressure (HP) for 3 hr. Survival times (ST) and oxygen arterial content (CaO2) have been measured in trouts exposed to HP = 101 ATA. The results show that at HP = 101 ATA, AMP increases (P less than 0.05) and ATP decreases (-12%; NS) in muscle but are not modified in brain; ST values are similar in normoxic and hyperoxic conditions, and CaO2 are similar at 1 ATA and 101 ATA of HP. It is concluded that HP tends to decrease aerobic production of energy. This phenomenon is not due to a failure in O2 transport from ambient medium to the cell but to a possible perturbation of the aerobic cellular processes leading to energy production (Krebs cycle and/or respiratory chain coupled to oxidative phosphorylation.
已测定暴露于101个绝对大气压静水压力（HP）3小时的鳗鱼脑和肌肉中的核苷酸浓度（三磷酸腺苷、二磷酸腺苷、一磷酸腺苷）。已测定暴露于HP = 101个绝对大气压的鳟鱼的存活时间（ST）和动脉血氧含量（CaO2）。结果表明，在HP = 101个绝对大气压时，肌肉中的一磷酸腺苷增加（P < 0.05），三磷酸腺苷减少（-12%；无统计学意义），但脑中无变化；常氧和高氧条件下的存活时间值相似，HP为1个绝对大气压和101个绝对大气压时的动脉血氧含量相似。得出的结论是，静水压力倾向于降低能量的有氧产生。这种现象不是由于氧气从周围介质向细胞转运失败，而是可能由于导致能量产生的有氧细胞过程（克雷布斯循环和/或与氧化磷酸化偶联的呼吸链）受到干扰。
