Zhang Bing, Dong Jia-Nan, Sun Ping, Feng Chong, Liu Yan-Cui
Department of Oncology, The Affiliated Hongqi Hospital of Mudanjiang Medical University Department of Rehabilitation Comprehensive Laboratory Department of Anatomy, Mudanjiang Medical University Department of Ultrasound, The Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China.
Medicine (Baltimore). 2017 Aug;96(33):e7750. doi: 10.1097/MD.0000000000007750.
This study aimed to evaluate the effect of therapeutic care (TC) for fatigue in breast cancer patients receiving chemotherapy.
A total of 48 breast cancer patients receiving chemotherapy were randomly divided into the intervention group and the control group, with 24 patients in each group. The patients in the intervention group were treated with TC, while the participants in the control group received the sham intervention. The interventions in both groups were for 30 min/d, 3 days weekly for 12 weeks. The primary outcome of fatigue was measured by the multidimensional fatigue inventory (MFI). The secondary outcomes were measured by the Hospital Anxiety and Depression Scale (HADS) and Pittsburgh Sleep Quality Index (PSQI). All outcomes were assessed before and after 6 and 12 weeks of the intervention.
The intervention with TC showed greater efficacy than sham TC in decreasing the MFI score after week 6 (P < .05) and week 12 (P < .01) of treatment. Significant differences were also found in the HADS and PSQI between the 2 groups after 12 weeks of treatment (P < .01).
This study demonstrated that TC might decrease fatigue and relieve the anxiety and depression of breast cancer patients receiving chemotherapy.
本研究旨在评估治疗性护理（TC）对接受化疗的乳腺癌患者疲劳的影响。
共有48例接受化疗的乳腺癌患者被随机分为干预组和对照组，每组24例。干预组患者接受TC治疗，而对照组参与者接受假干预。两组干预均为每天30分钟，每周3天，共12周。疲劳的主要结局通过多维疲劳量表（MFI）测量。次要结局通过医院焦虑抑郁量表（HADS）和匹兹堡睡眠质量指数（PSQI）测量。所有结局在干预6周和12周前后进行评估。
在治疗第6周（P<0.05）和第12周（P<0.01）后，TC干预在降低MFI评分方面显示出比假TC更高的疗效。治疗12周后，两组在HADS和PSQI方面也发现了显著差异（P<0.01）。
本研究表明，TC可能会减轻接受化疗的乳腺癌患者的疲劳，并缓解其焦虑和抑郁。
